| http://purl.uniprot.org/citations/35089129 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35089129 | http://www.w3.org/2000/01/rdf-schema#comment | "Advancing age causes reduced hippocampal neurogenesis, associated with age-related cognitive decline. The spatial relationship of age-induced alterations in neural stem cells (NSCs) and surrounding cells within the hippocampal niche remains poorly understood due to limitations of antibody-based cellular phenotyping. We established iterative indirect immunofluorescence imaging (4i) in tissue sections, allowing for simultaneous detection of 18 proteins to characterize NSCs and surrounding cells in 2-, 6-, and 12-month-old mice. We show that reorganization of the dentate gyrus (DG) niche already occurs in middle-aged mice, paralleling the decline in neurogenesis. 4i-based tissue analysis of the DG identifies changes in cell-type contributions to the blood-brain barrier and microenvironments surrounding NSCs to play a pivotal role to preserve neurogenic permissiveness. The data provided represent a resource to characterize the principles causing alterations of stem cell-associated plasticity within the aging DG and provide a blueprint to analyze somatic stem cell niches across lifespan in complex tissues."xsd:string |
| http://purl.uniprot.org/citations/35089129 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.68000"xsd:string |
| http://purl.uniprot.org/citations/35089129 | http://purl.uniprot.org/core/author | "Pelkmans L."xsd:string |
| http://purl.uniprot.org/citations/35089129 | http://purl.uniprot.org/core/author | "Jessberger S."xsd:string |
| http://purl.uniprot.org/citations/35089129 | http://purl.uniprot.org/core/author | "Gonzalez-Bohorquez D."xsd:string |
| http://purl.uniprot.org/citations/35089129 | http://purl.uniprot.org/core/author | "Cole J.D."xsd:string |
| http://purl.uniprot.org/citations/35089129 | http://purl.uniprot.org/core/author | "Gut G."xsd:string |
| http://purl.uniprot.org/citations/35089129 | http://purl.uniprot.org/core/author | "Sarabia Del Castillo J."xsd:string |
| http://purl.uniprot.org/citations/35089129 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35089129 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/35089129 | http://purl.uniprot.org/core/pages | "e68000"xsd:string |
| http://purl.uniprot.org/citations/35089129 | http://purl.uniprot.org/core/title | "Characterization of the neurogenic niche in the aging dentate gyrus using iterative immunofluorescence imaging."xsd:string |
| http://purl.uniprot.org/citations/35089129 | http://purl.uniprot.org/core/volume | "11"xsd:string |
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