DESCRIBE <http://purl.uniprot.org/citations/35093273>

Subject	Predicate	Object
http://purl.uniprot.org/citations/35093273	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/35093273	http://www.w3.org/2000/01/rdf-schema#comment	" Background Epigenetic alterations have been reported as one of the risk factors of gallbladder cancer. Promoter hypermethylation is associated with high incidence and poor prognosis of GBC. Bcl-2/adenovirus E1B 19 kDa interacting protein 3 is a pro-apoptotic protein member of Bcl-2 family. Aims Present study was aimed to investigate expression profile and promoter methylation status of BNIP3 in GBC and its correlation with clinico-pathological parameters. Methods The expression analysis and methylation status of BNIP3 was performed by semi-quantitative reverse transcription polymerase chain reaction and Methylation-specific polymerase chain reaction respectively in 84 GBC patients and 29 gallstone tissues (used as normal controls). Results We demonstrate down regulation of BNIP3 in 56% of the GBC samples. BNIP3 promoter is also frequently hypermethylated (69%) in GBC samples. Interestingly, we found that 69% (40/58) of the BNIP3 promoter hypermethylated samples had also reduced expression of BNIP3. Our data demonstrate significant correlation of the mRNA expression and promoter hypermethylation with late stage and nodal metastasis. Hypermethylation of BNIP3 promoter is associated with low overall survival period. Conclusion Our results suggest that promoter hypermethylation is an early event and can be a frequent mechanism for downregulation of BNIP3 in GBC."xsd:string
http://purl.uniprot.org/citations/35093273	http://purl.org/dc/terms/identifier	"doi:10.1016/j.dld.2022.01.121"xsd:string
http://purl.uniprot.org/citations/35093273	http://purl.uniprot.org/core/author	"Singh S."xsd:string
http://purl.uniprot.org/citations/35093273	http://purl.uniprot.org/core/author	"Bharti A."xsd:string
http://purl.uniprot.org/citations/35093273	http://purl.uniprot.org/core/author	"Singh D."xsd:string
http://purl.uniprot.org/citations/35093273	http://purl.uniprot.org/core/author	"Narayan G."xsd:string
http://purl.uniprot.org/citations/35093273	http://purl.uniprot.org/core/author	"Tewari M."xsd:string
http://purl.uniprot.org/citations/35093273	http://purl.uniprot.org/core/author	"Ansari M.A."xsd:string
http://purl.uniprot.org/citations/35093273	http://purl.uniprot.org/core/author	"Kar A.G."xsd:string
http://purl.uniprot.org/citations/35093273	http://purl.uniprot.org/core/date	"2022"xsd:gYear
http://purl.uniprot.org/citations/35093273	http://purl.uniprot.org/core/name	"Dig Liver Dis"xsd:string
http://purl.uniprot.org/citations/35093273	http://purl.uniprot.org/core/pages	"1257-1263"xsd:string
http://purl.uniprot.org/citations/35093273	http://purl.uniprot.org/core/title	"Frequent promoter hypermethylation and down regulation of BNIP3: An early event during gallbladder cancer progression."xsd:string
http://purl.uniprot.org/citations/35093273	http://purl.uniprot.org/core/volume	"54"xsd:string
http://purl.uniprot.org/citations/35093273	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/35093273
http://purl.uniprot.org/citations/35093273	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/35093273
http://purl.uniprot.org/uniprot/#_A0A2U8ZU93-mappedCitation-35093273	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/35093273
http://purl.uniprot.org/uniprot/#_B4DHJ7-mappedCitation-35093273	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/35093273
http://purl.uniprot.org/uniprot/#_Q12983-mappedCitation-35093273	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/35093273
http://purl.uniprot.org/uniprot/#_Q53HF4-mappedCitation-35093273	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/35093273
http://purl.uniprot.org/uniprot/#_Q66K24-mappedCitation-35093273	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/35093273
http://purl.uniprot.org/uniprot/#_Q6NVY4-mappedCitation-35093273	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/35093273
http://purl.uniprot.org/uniprot/Q53HF4	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/35093273
http://purl.uniprot.org/uniprot/Q12983	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/35093273