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http://purl.uniprot.org/citations/35093868http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/35093868http://www.w3.org/2000/01/rdf-schema#comment"

Background/aim

We investigated whether promoter methylation of the checkpoint-with-forkhead-and-ring-finger-domains (CHFR) gene is a predictor of the efficacy of irinotecan-based systemic chemotherapy for advanced colorectal cancer (CRC) patients.

Materials and methods

CHFR-promoter methylation was measured by quantitative methylation-specific PCR (qMSP). The histoculture drug response assay (HDRA) was used in vitro to analyze the correlation between CHFR-promoter methylation and the efficacy of the irinotecan-active-metabolite SN38 in colorectal-cancer tissues from 44 CRC patients. CHFR promoter-methylation was also analyzed for its correlation with clinical response to irinotecan-based systemic chemotherapy of 49 CRC patients.

Results

CHFR-promoter methylation significantly-positively correlated with inhibition of colon cancer by SN38 in the HDRA (p=0.002). CHFR-promoter methylation also significantly-positively correlated with clinical response to irinotecan-based systemic chemotherapy (p=0.04 for disease control). CHFR-promoter methylation also significantly-positively correlated (p=0.01) with increased progression-free survival for patients treated with irinotecan-containing FLOFIRI in combination with bevacizumab, the most-frequent regimen in the cohort.

Conclusion

Sensitivity of advanced CRC patients to irinotecan-based systemic chemotherapy can be predicted by the extent of CHFR-promoter methylation."xsd:string
http://purl.uniprot.org/citations/35093868http://purl.org/dc/terms/identifier"doi:10.21873/anticanres.15528"xsd:string
http://purl.uniprot.org/citations/35093868http://purl.uniprot.org/core/author"Kawano S."xsd:string
http://purl.uniprot.org/citations/35093868http://purl.uniprot.org/core/author"Sugimoto K."xsd:string
http://purl.uniprot.org/citations/35093868http://purl.uniprot.org/core/author"Sakamoto K."xsd:string
http://purl.uniprot.org/citations/35093868http://purl.uniprot.org/core/author"Takahashi M."xsd:string
http://purl.uniprot.org/citations/35093868http://purl.uniprot.org/core/author"Irie T."xsd:string
http://purl.uniprot.org/citations/35093868http://purl.uniprot.org/core/author"Kojima Y."xsd:string
http://purl.uniprot.org/citations/35093868http://purl.uniprot.org/core/author"Kawai M."xsd:string
http://purl.uniprot.org/citations/35093868http://purl.uniprot.org/core/author"Hagiwara T."xsd:string
http://purl.uniprot.org/citations/35093868http://purl.uniprot.org/core/author"Serizawa N."xsd:string
http://purl.uniprot.org/citations/35093868http://purl.uniprot.org/core/author"Hoffman R.M."xsd:string
http://purl.uniprot.org/citations/35093868http://purl.uniprot.org/core/author"Honjo K."xsd:string
http://purl.uniprot.org/citations/35093868http://purl.uniprot.org/core/author"Momose H."xsd:string
http://purl.uniprot.org/citations/35093868http://purl.uniprot.org/core/author"Brock M.V."xsd:string
http://purl.uniprot.org/citations/35093868http://purl.uniprot.org/core/author"Nagahara A."xsd:string
http://purl.uniprot.org/citations/35093868http://purl.uniprot.org/core/author"Munakata S."xsd:string
http://purl.uniprot.org/citations/35093868http://purl.uniprot.org/core/author"Okazawa Y.U."xsd:string
http://purl.uniprot.org/citations/35093868http://purl.uniprot.org/core/date"2022"xsd:gYear
http://purl.uniprot.org/citations/35093868http://purl.uniprot.org/core/name"Anticancer Res"xsd:string
http://purl.uniprot.org/citations/35093868http://purl.uniprot.org/core/pages"697-707"xsd:string
http://purl.uniprot.org/citations/35093868http://purl.uniprot.org/core/title"CHFR-Promoter-Methylation Status Is Predictive of Response to Irinotecan-based Systemic Chemotherapy in Advanced Colorectal Cancer."xsd:string
http://purl.uniprot.org/citations/35093868http://purl.uniprot.org/core/volume"42"xsd:string
http://purl.uniprot.org/citations/35093868http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/35093868
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