| http://purl.uniprot.org/citations/35103284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35103284 | http://www.w3.org/2000/01/rdf-schema#comment | "The contractile phenotype of smooth muscle cells (SMCs) is transcriptionally controlled by a complex of the DNA-binding protein SRF and the transcriptional co-activator MYOCD. The pathways that activate expression of Myocd and of SMC structural genes in mesenchymal progenitors are diverse, reflecting different intrinsic and extrinsic signaling inputs. Taking the ureter as a model, we analyzed whether Notch signaling, a pathway previously implicated in vascular SMC development, also affects visceral SMC differentiation. We show that mice with a conditional deletion of the unique Notch mediator RBPJ in the undifferentiated ureteric mesenchyme exhibit altered ureter peristalsis with a delayed onset, and decreased contraction frequency and intensity at fetal stages. They also develop hydroureter 2 weeks after birth. Notch signaling is required for precise temporal activation of Myocd expression and, independently, for expression of a group of late SMC structural genes. Based on additional expression analyses, we suggest that a mesenchymal JAG1-NOTCH2/NOTCH3 module regulates visceral SMC differentiation in the ureter in a biphasic and bimodal manner, and that its molecular function differs from that in the vascular system."xsd:string |
| http://purl.uniprot.org/citations/35103284 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.199735"xsd:string |
| http://purl.uniprot.org/citations/35103284 | http://purl.uniprot.org/core/author | "Kaur J."xsd:string |
| http://purl.uniprot.org/citations/35103284 | http://purl.uniprot.org/core/author | "Kispert A."xsd:string |
| http://purl.uniprot.org/citations/35103284 | http://purl.uniprot.org/core/author | "Rudat C."xsd:string |
| http://purl.uniprot.org/citations/35103284 | http://purl.uniprot.org/core/author | "Trowe M.O."xsd:string |
| http://purl.uniprot.org/citations/35103284 | http://purl.uniprot.org/core/author | "Weiss A.C."xsd:string |
| http://purl.uniprot.org/citations/35103284 | http://purl.uniprot.org/core/author | "Hildebrandt H."xsd:string |
| http://purl.uniprot.org/citations/35103284 | http://purl.uniprot.org/core/author | "Kurz J."xsd:string |
| http://purl.uniprot.org/citations/35103284 | http://purl.uniprot.org/core/author | "Wojahn I."xsd:string |
| http://purl.uniprot.org/citations/35103284 | http://purl.uniprot.org/core/author | "Thiesler H."xsd:string |
| http://purl.uniprot.org/citations/35103284 | http://purl.uniprot.org/core/author | "Ludtke T.H."xsd:string |
| http://purl.uniprot.org/citations/35103284 | http://purl.uniprot.org/core/author | "Deuper L."xsd:string |
| http://purl.uniprot.org/citations/35103284 | http://purl.uniprot.org/core/author | "Qasrawi F."xsd:string |
| http://purl.uniprot.org/citations/35103284 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35103284 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/35103284 | http://purl.uniprot.org/core/pages | "dev199735"xsd:string |
| http://purl.uniprot.org/citations/35103284 | http://purl.uniprot.org/core/title | "Notch signaling is a novel regulator of visceral smooth muscle cell differentiation in the murine ureter."xsd:string |
| http://purl.uniprot.org/citations/35103284 | http://purl.uniprot.org/core/volume | "149"xsd:string |
| http://purl.uniprot.org/citations/35103284 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35103284 |
| http://purl.uniprot.org/citations/35103284 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35103284 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVW7-mappedCitation-35103284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35103284 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVX7-mappedCitation-35103284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35103284 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWC4-mappedCitation-35103284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35103284 |