| http://purl.uniprot.org/citations/35107038 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35107038 | http://www.w3.org/2000/01/rdf-schema#comment | "Perinatal hypoxic/ischemic (HI) brain injury is a major clinical problem with devastating neurodevelopmental outcomes in neonates. During HI brain injury, dysregulated factor production contributes to microvascular impairment. Glycolysis-derived lactate accumulated during ischemia has been proposed to protect against ischemic injury, but its mechanism of action is poorly understood. Herein, we hypothesize that lactate via its G-protein coupled receptor (GPR81) controls postnatal brain angiogenesis and plays a protective role after HI injury. We show that GPR81 is predominantly expressed in neurons of the cerebral cortex and hippocampus. GPR81-null mice displayed a delay in cerebral microvascular development linked to reduced levels of various major angiogenic factors and augmented expression of anti-angiogenic Thrombospondin-1 (TSP-1) in comparison to their WT littermates. Coherently, lactate stimulation induced an increase in growth factors (VEGF, Ang1 and 2, PDGF) and reduced TSP-1 expression in neurons, which contributed to accelerating angiogenesis. HI injury in GPR81-null animals curtailed vascular density and consequently increased infarct size compared to changes seen in WT mice; conversely intracerebroventricular lactate injection increased vascular density and diminished infarct size in WT but not in GPR81-null mice. Collectively, we show that lactate acting via GPR81 participates in developmental brain angiogenesis, and attenuates HI injury by restoring compromised microvasculature."xsd:string |
| http://purl.uniprot.org/citations/35107038 | http://purl.org/dc/terms/identifier | "doi:10.1177/0271678x221077499"xsd:string |
| http://purl.uniprot.org/citations/35107038 | http://purl.uniprot.org/core/author | "Pineyro G."xsd:string |
| http://purl.uniprot.org/citations/35107038 | http://purl.uniprot.org/core/author | "Hou X."xsd:string |
| http://purl.uniprot.org/citations/35107038 | http://purl.uniprot.org/core/author | "Chemtob S."xsd:string |
| http://purl.uniprot.org/citations/35107038 | http://purl.uniprot.org/core/author | "Chaudhari P."xsd:string |
| http://purl.uniprot.org/citations/35107038 | http://purl.uniprot.org/core/author | "Rivera J.C."xsd:string |
| http://purl.uniprot.org/citations/35107038 | http://purl.uniprot.org/core/author | "Lodygensky G."xsd:string |
| http://purl.uniprot.org/citations/35107038 | http://purl.uniprot.org/core/author | "Madaan A."xsd:string |
| http://purl.uniprot.org/citations/35107038 | http://purl.uniprot.org/core/author | "Charfi I."xsd:string |
| http://purl.uniprot.org/citations/35107038 | http://purl.uniprot.org/core/author | "Habelrih T."xsd:string |
| http://purl.uniprot.org/citations/35107038 | http://purl.uniprot.org/core/author | "Muanza T."xsd:string |
| http://purl.uniprot.org/citations/35107038 | http://purl.uniprot.org/core/author | "Nezhady M."xsd:string |
| http://purl.uniprot.org/citations/35107038 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35107038 | http://purl.uniprot.org/core/name | "J Cereb Blood Flow Metab"xsd:string |
| http://purl.uniprot.org/citations/35107038 | http://purl.uniprot.org/core/pages | "1294-1308"xsd:string |
| http://purl.uniprot.org/citations/35107038 | http://purl.uniprot.org/core/title | "Neuronal GPR81 regulates developmental brain angiogenesis and promotes brain recovery after a hypoxic ischemic insult."xsd:string |
| http://purl.uniprot.org/citations/35107038 | http://purl.uniprot.org/core/volume | "42"xsd:string |
| http://purl.uniprot.org/citations/35107038 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35107038 |
| http://purl.uniprot.org/citations/35107038 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35107038 |
| http://purl.uniprot.org/uniprot/#_E9PZR8-mappedCitation-35107038 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35107038 |
| http://purl.uniprot.org/uniprot/#_A0A4Y1JWM1-mappedCitation-35107038 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35107038 |
| http://purl.uniprot.org/uniprot/#_B9UM22-mappedCitation-35107038 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35107038 |
| http://purl.uniprot.org/uniprot/#_Q8C131-mappedCitation-35107038 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35107038 |