| http://purl.uniprot.org/citations/35108124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35108124 | http://www.w3.org/2000/01/rdf-schema#comment | "Heme oxygenase function is highly conserved between vertebrates where it plays important roles in normal embryonic development and controls oxidative stress. Expression of the zebrafish heme oxygenase 1 genes is known to be responsive to oxidative stress suggesting a conserved physiological function. In this study, we generate a knockout allele of zebrafish hmox1a and characterize the effects of hmox1a and hmox1b loss on embryonic development. We find that loss of hmox1a or hmox1b causes developmental defects in only a minority of embryos, in contrast to Hmox1 gene deletions in mice that cause loss of most embryos. Using a tail wound inflammation assay we find a conserved role for hmox1a, but not hmox1b, in normal macrophage migration to the wound site. Together our results indicate that zebrafish hmox1a has clearly a partitioned role from hmox1b that is more consistent with conserved functions of mammalian Heme oxygenase 1."xsd:string |
| http://purl.uniprot.org/citations/35108124 | http://purl.org/dc/terms/identifier | "doi:10.1089/zeb.2021.0058"xsd:string |
| http://purl.uniprot.org/citations/35108124 | http://purl.uniprot.org/core/author | "Kikuchi K."xsd:string |
| http://purl.uniprot.org/citations/35108124 | http://purl.uniprot.org/core/author | "Ogawa M."xsd:string |
| http://purl.uniprot.org/citations/35108124 | http://purl.uniprot.org/core/author | "Stocker R."xsd:string |
| http://purl.uniprot.org/citations/35108124 | http://purl.uniprot.org/core/author | "Britton W.J."xsd:string |
| http://purl.uniprot.org/citations/35108124 | http://purl.uniprot.org/core/author | "Luo K."xsd:string |
| http://purl.uniprot.org/citations/35108124 | http://purl.uniprot.org/core/author | "Oehlers S.H."xsd:string |
| http://purl.uniprot.org/citations/35108124 | http://purl.uniprot.org/core/author | "Ayer A."xsd:string |
| http://purl.uniprot.org/citations/35108124 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35108124 | http://purl.uniprot.org/core/name | "Zebrafish"xsd:string |
| http://purl.uniprot.org/citations/35108124 | http://purl.uniprot.org/core/pages | "7-17"xsd:string |
| http://purl.uniprot.org/citations/35108124 | http://purl.uniprot.org/core/title | "Zebrafish Heme Oxygenase 1a Is Necessary for Normal Development and Macrophage Migration."xsd:string |
| http://purl.uniprot.org/citations/35108124 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/35108124 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35108124 |
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