| http://purl.uniprot.org/citations/35122571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35122571 | http://www.w3.org/2000/01/rdf-schema#comment | "Honeysuckle Lonicera pallasii (Lonicera caerulea L.) is an excellent source of anthocyanins which have a number of health-promoting properties mainly associated with antioxidant and anti-inflammatory activities. Cyanidin-3-O-glucoside (C3G) is one of the most common anthocyanins naturally found in honeysuckle. The goal of the present study was to investigate antioxidant and anti-aging properties of Lonicera pallasii (Lonicera caerulea L.) extract (LE) and C3G using red blood cells (RBC) and Drosophila melanogaster models. LE and C3G treatment at a concentration of 100 μM induced enhancement of median and maximum lifespan up to 8%. LE and C3G supplementation at a concentration of 100 μM increased stress resistance up to 10%. The locomotor activity decreased during LE and C3G treatment in 4 and 6 weeks up to 52% in females. The integrity of the intestinal barrier was increased by 4% after LE treatment. These effects were accompanied by increased expression of Hif1 (pro-longevity gene) in response to C3G treatment and decreased expression of Keap1 (anti-longevity gene) after C3G and LE supplementation. RNA interference-mediated knockdown of Sirt6 completely abolished the positive effect obtained of LE and C3G supplementation in males which indicates that lifespan-extending effect is associated with Sirt6 activation. The experiments on the various in-vitro models (including radical scavenging activity and oxidative hemolysis of RBC demonstrated antioxidant and membrane-protective activities of LE and C3G. The present study indicates that Lonicera extract can prolong the lifespan and improve the healthspan of Drosophila model through biological and antioxidant activities."xsd:string |
| http://purl.uniprot.org/citations/35122571 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10522-022-09954-1"xsd:string |
| http://purl.uniprot.org/citations/35122571 | http://purl.uniprot.org/core/author | "Shevchenko O."xsd:string |
| http://purl.uniprot.org/citations/35122571 | http://purl.uniprot.org/core/author | "Moskalev A."xsd:string |
| http://purl.uniprot.org/citations/35122571 | http://purl.uniprot.org/core/author | "Shaposhnikov M."xsd:string |
| http://purl.uniprot.org/citations/35122571 | http://purl.uniprot.org/core/author | "Zemskaya N."xsd:string |
| http://purl.uniprot.org/citations/35122571 | http://purl.uniprot.org/core/author | "Golubev D."xsd:string |
| http://purl.uniprot.org/citations/35122571 | http://purl.uniprot.org/core/author | "Kukuman D."xsd:string |
| http://purl.uniprot.org/citations/35122571 | http://purl.uniprot.org/core/author | "Patov S."xsd:string |
| http://purl.uniprot.org/citations/35122571 | http://purl.uniprot.org/core/author | "Punegov V."xsd:string |
| http://purl.uniprot.org/citations/35122571 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35122571 | http://purl.uniprot.org/core/name | "Biogerontology"xsd:string |
| http://purl.uniprot.org/citations/35122571 | http://purl.uniprot.org/core/pages | "215-235"xsd:string |
| http://purl.uniprot.org/citations/35122571 | http://purl.uniprot.org/core/title | "Honeysuckle extract (Lonicera pallasii L.) exerts antioxidant properties and extends the lifespan and healthspan of Drosophila melanogaster."xsd:string |
| http://purl.uniprot.org/citations/35122571 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/35122571 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35122571 |
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