| http://purl.uniprot.org/citations/35145145 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35145145 | http://www.w3.org/2000/01/rdf-schema#comment | "Myocardin-related transcription factor A (MRTF-A), a coactivator of serum response factor (SRF), regulates the expression of many cytoskeletal genes in response to cytoplasmic and nuclear actin dynamics. Here we describe a novel mechanism to regulate MRTF-A activity within the nucleus by showing that lamina-associated polypeptide 2α (Lap2α), the nucleoplasmic isoform of Lap2, is a direct binding partner of MRTF-A, and required for the efficient expression of MRTF-A/SRF target genes. Mechanistically, Lap2α is not required for MRTF-A nuclear localization, unlike most other MRTF-A regulators, but is required for efficient recruitment of MRTF-A to its target genes. This regulatory step takes place prior to MRTF-A chromatin binding, because Lap2α neither interacts with, nor specifically influences active histone marks on MRTF-A/SRF target genes. Phenotypically, Lap2α is required for serum-induced cell migration, and deregulated MRTF-A activity may also contribute to muscle and proliferation phenotypes associated with loss of Lap2α. Our studies therefore add another regulatory layer to the control of MRTF-A-SRF-mediated gene expression, and broaden the role of Lap2α in transcriptional regulation."xsd:string |
| http://purl.uniprot.org/citations/35145145 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-022-06135-5"xsd:string |
| http://purl.uniprot.org/citations/35145145 | http://purl.uniprot.org/core/author | "Sokolova M."xsd:string |
| http://purl.uniprot.org/citations/35145145 | http://purl.uniprot.org/core/author | "Foisner R."xsd:string |
| http://purl.uniprot.org/citations/35145145 | http://purl.uniprot.org/core/author | "Vartiainen M.K."xsd:string |
| http://purl.uniprot.org/citations/35145145 | http://purl.uniprot.org/core/author | "Posern G."xsd:string |
| http://purl.uniprot.org/citations/35145145 | http://purl.uniprot.org/core/author | "Kyheroinen S."xsd:string |
| http://purl.uniprot.org/citations/35145145 | http://purl.uniprot.org/core/author | "Pennanen A.P."xsd:string |
| http://purl.uniprot.org/citations/35145145 | http://purl.uniprot.org/core/author | "Sidorenko E."xsd:string |
| http://purl.uniprot.org/citations/35145145 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35145145 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/35145145 | http://purl.uniprot.org/core/pages | "2306"xsd:string |
| http://purl.uniprot.org/citations/35145145 | http://purl.uniprot.org/core/title | "Lamina-associated polypeptide 2alpha is required for intranuclear MRTF-A activity."xsd:string |
| http://purl.uniprot.org/citations/35145145 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/35145145 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35145145 |
| http://purl.uniprot.org/citations/35145145 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35145145 |
| http://purl.uniprot.org/uniprot/#_A0A5F8MQ33-mappedCitation-35145145 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35145145 |
| http://purl.uniprot.org/uniprot/#_A0A668KL76-mappedCitation-35145145 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35145145 |
| http://purl.uniprot.org/uniprot/#_D3YUG5-mappedCitation-35145145 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35145145 |
| http://purl.uniprot.org/uniprot/#_D3YUI2-mappedCitation-35145145 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35145145 |
| http://purl.uniprot.org/uniprot/#_Q3TXQ1-mappedCitation-35145145 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35145145 |
| http://purl.uniprot.org/uniprot/#_Q3UR33-mappedCitation-35145145 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35145145 |
| http://purl.uniprot.org/uniprot/#_Q3U955-mappedCitation-35145145 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35145145 |
| http://purl.uniprot.org/uniprot/#_Q3TNH0-mappedCitation-35145145 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35145145 |