| http://purl.uniprot.org/citations/35156727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35156727 | http://www.w3.org/2000/01/rdf-schema#comment | "While PAX5 is an important tumor suppressor gene in B-cell acute lymphoblastic leukemia (B-ALL), it is also involved in oncogenic translocations coding for diverse PAX5 fusion proteins. PAX5-JAK2 encodes a protein consisting of the PAX5 DNA-binding region fused to the constitutively active JAK2 kinase domain. Here, we studied the oncogenic function of the PAX5-JAK2 fusion protein in a mouse model expressing it from the endogenous Pax5 locus, resulting in inactivation of one of the two Pax5 alleles. Pax5Jak2/+ mice rapidly developed an aggressive B-ALL in the absence of another cooperating exogenous gene mutation. The DNA-binding function and kinase activity of Pax5-Jak2 as well as IL-7 signaling contributed to leukemia development. Interestingly, all Pax5Jak2/+ tumors lost the remaining wild-type Pax5 allele, allowing efficient DNA-binding of Pax5-Jak2. While we could not find evidence for a nuclear role of Pax5-Jak2 as an epigenetic regulator, high levels of active phosphorylated STAT5 and increased expression of STAT5 target genes were seen in Pax5Jak2/+ B-ALL tumors, implying that nuclear Pax5-Jak2 phosphorylates STAT5. Together, these data reveal Pax5-Jak2 as an important nuclear driver of leukemogenesis by maintaining phosphorylated STAT5 levels in the nucleus."xsd:string |
| http://purl.uniprot.org/citations/35156727 | http://purl.org/dc/terms/identifier | "doi:10.15252/embj.2021108397"xsd:string |
| http://purl.uniprot.org/citations/35156727 | http://purl.uniprot.org/core/author | "Fischer M."xsd:string |
| http://purl.uniprot.org/citations/35156727 | http://purl.uniprot.org/core/author | "Jurado S."xsd:string |
| http://purl.uniprot.org/citations/35156727 | http://purl.uniprot.org/core/author | "Busslinger M."xsd:string |
| http://purl.uniprot.org/citations/35156727 | http://purl.uniprot.org/core/author | "Jaritz M."xsd:string |
| http://purl.uniprot.org/citations/35156727 | http://purl.uniprot.org/core/author | "Mullighan C.G."xsd:string |
| http://purl.uniprot.org/citations/35156727 | http://purl.uniprot.org/core/author | "Kostanova-Poliakova D."xsd:string |
| http://purl.uniprot.org/citations/35156727 | http://purl.uniprot.org/core/author | "Strehl S."xsd:string |
| http://purl.uniprot.org/citations/35156727 | http://purl.uniprot.org/core/author | "Malin S.G."xsd:string |
| http://purl.uniprot.org/citations/35156727 | http://purl.uniprot.org/core/author | "Fedl A.S."xsd:string |
| http://purl.uniprot.org/citations/35156727 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35156727 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/35156727 | http://purl.uniprot.org/core/pages | "e108397"xsd:string |
| http://purl.uniprot.org/citations/35156727 | http://purl.uniprot.org/core/title | "The PAX5-JAK2 translocation acts as dual-hit mutation that promotes aggressive B-cell leukemia via nuclear STAT5 activation."xsd:string |
| http://purl.uniprot.org/citations/35156727 | http://purl.uniprot.org/core/volume | "41"xsd:string |
| http://purl.uniprot.org/citations/35156727 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35156727 |
| http://purl.uniprot.org/citations/35156727 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35156727 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVX2-mappedCitation-35156727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35156727 |
| http://purl.uniprot.org/uniprot/#_A0A087WST9-mappedCitation-35156727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35156727 |
| http://purl.uniprot.org/uniprot/#_A2A5D3-mappedCitation-35156727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35156727 |
| http://purl.uniprot.org/uniprot/#_A2A5D4-mappedCitation-35156727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35156727 |
| http://purl.uniprot.org/uniprot/#_A2AKM5-mappedCitation-35156727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35156727 |
| http://purl.uniprot.org/uniprot/#_A2AKM6-mappedCitation-35156727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35156727 |