| http://purl.uniprot.org/citations/35162104 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35162104 | http://www.w3.org/2000/01/rdf-schema#comment | "Given the increasing prevalence of frailty and its implications for public health, the identification of biomarkers to detect frailty is essential. Sestrin-1 is a protein with a protective role in muscle function. This study aimed to determine whether the serum sestrin-1 concentration differed between frail and non-frail populations and to investigate its association with frailty-related variables in 225 older women and men living in nursing homes (Gipuzkoa, Spain). Serum sestrin-1 concentration was measured by ELISA. Frailty, dependence, anthropometry, physical function, and physical activity were determined by validated tests and tools. The associations between sestrin-1 concentration and the other variables were determined using generalized linear models. The differences between frail and non-frail individuals were analyzed by the Mann-Whitney U-test, and receiver operating characteristic (ROC) curves were constructed to calculate the capability of sestrin-1 to detect frailty. Unexpectedly, frail individuals-according to the Fried Frailty Phenotype or the Clinical Frailty Scale-had higher serum sestrin-1 concentrations than non-frail individuals. Furthermore, the higher serum sestrin-1 concentration was associated with the increased frailty scores and dependence as well as the poorer physical function and the less physical activity. Given the contradictory results regarding serum sestrin-1 and frailty, further investigation is required to propose it as a molecular biomarker of frailty."xsd:string |
| http://purl.uniprot.org/citations/35162104 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijerph19031079"xsd:string |
| http://purl.uniprot.org/citations/35162104 | http://purl.uniprot.org/core/author | "Arrieta H."xsd:string |
| http://purl.uniprot.org/citations/35162104 | http://purl.uniprot.org/core/author | "Irazusta J."xsd:string |
| http://purl.uniprot.org/citations/35162104 | http://purl.uniprot.org/core/author | "Molano I."xsd:string |
| http://purl.uniprot.org/citations/35162104 | http://purl.uniprot.org/core/author | "Sanz B."xsd:string |
| http://purl.uniprot.org/citations/35162104 | http://purl.uniprot.org/core/author | "Rezola-Pardo C."xsd:string |
| http://purl.uniprot.org/citations/35162104 | http://purl.uniprot.org/core/author | "Rodriguez-Larrad A."xsd:string |
| http://purl.uniprot.org/citations/35162104 | http://purl.uniprot.org/core/author | "Alonso-Puyo J."xsd:string |
| http://purl.uniprot.org/citations/35162104 | http://purl.uniprot.org/core/author | "Fraile-Bermudez A.B."xsd:string |
| http://purl.uniprot.org/citations/35162104 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35162104 | http://purl.uniprot.org/core/name | "Int J Environ Res Public Health"xsd:string |
| http://purl.uniprot.org/citations/35162104 | http://purl.uniprot.org/core/pages | "1079"xsd:string |
| http://purl.uniprot.org/citations/35162104 | http://purl.uniprot.org/core/title | "Serum Sestrin-1 Concentration Is Higher in Frail than Non-Frail Older People Living in Nursing Homes."xsd:string |
| http://purl.uniprot.org/citations/35162104 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/35162104 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35162104 |
| http://purl.uniprot.org/citations/35162104 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35162104 |
| http://purl.uniprot.org/uniprot/#_A8K292-mappedCitation-35162104 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35162104 |
| http://purl.uniprot.org/uniprot/#_A8K3D6-mappedCitation-35162104 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35162104 |
| http://purl.uniprot.org/uniprot/#_Q9Y6P5-mappedCitation-35162104 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35162104 |
| http://purl.uniprot.org/uniprot/A8K292 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/35162104 |
| http://purl.uniprot.org/uniprot/Q9Y6P5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/35162104 |
| http://purl.uniprot.org/uniprot/A8K3D6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/35162104 |