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| http://purl.uniprot.org/citations/35167937 | http://www.w3.org/2000/01/rdf-schema#comment | "Farnesyltransferase (FTase) enables about 100 proteins to interact with cellular membranes by catalyzing the posttranslational addition of a farnesyl group. Farnesylated proteins provide important functions and inhibitors against the β-subunit of the heterodimer of FTase are intensively studied in clinical and preclinical trials. However, very little is known about the transcriptional regulation of the β-subunit. The examined promoter region of the human FTase β-subunit gene (FNTB) showed significant basal promoter activity in HEK-293 and in HeLa cells. We were able to locate the core promoter at -165 to -74. Ten potential binding sites of the transcription factor OCT-1 were detected. Three could be confirmed using EMSA super shift experiments. OCT-1 overexpression and knockdown confirmed it as an important regulator of FNTB expression. Our results provide a basis for further research on FNTB/OCT-1 regulation, its inhibitors and diseases influenced by both such as colon carcinoma or diabetes mellitus."xsd:string |
| http://purl.uniprot.org/citations/35167937 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ygeno.2022.110314"xsd:string |
| http://purl.uniprot.org/citations/35167937 | http://purl.uniprot.org/core/author | "Hagemann A."xsd:string |
| http://purl.uniprot.org/citations/35167937 | http://purl.uniprot.org/core/author | "Jung D."xsd:string |
| http://purl.uniprot.org/citations/35167937 | http://purl.uniprot.org/core/author | "Manthey I."xsd:string |
| http://purl.uniprot.org/citations/35167937 | http://purl.uniprot.org/core/author | "Domin M."xsd:string |
| http://purl.uniprot.org/citations/35167937 | http://purl.uniprot.org/core/author | "Bachmann H.S."xsd:string |
| http://purl.uniprot.org/citations/35167937 | http://purl.uniprot.org/core/author | "Stelmach P."xsd:string |
| http://purl.uniprot.org/citations/35167937 | http://purl.uniprot.org/core/author | "Verhasselt H."xsd:string |
| http://purl.uniprot.org/citations/35167937 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35167937 | http://purl.uniprot.org/core/name | "Genomics"xsd:string |
| http://purl.uniprot.org/citations/35167937 | http://purl.uniprot.org/core/pages | "110314"xsd:string |
| http://purl.uniprot.org/citations/35167937 | http://purl.uniprot.org/core/title | "Characterization of the promoter of the human farnesyltransferase beta subunit and the impact of the transcription factor OCT-1 on its expression."xsd:string |
| http://purl.uniprot.org/citations/35167937 | http://purl.uniprot.org/core/volume | "114"xsd:string |
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