| http://purl.uniprot.org/citations/35169076 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35169076 | http://www.w3.org/2000/01/rdf-schema#comment | "Retrotransposons are genomic DNA sequences that copy themselves to new genomic locations via RNA intermediates; LINE-1 is the only active and autonomous retrotransposon in the human genome. The mobility of LINE-1 is largely repressed in somatic tissues but is derepressed in many cancers, where LINE-1 retrotransposition is correlated with p53 mutation and copy number alteration (CNA). In cell lines, inducing LINE-1 expression can cause double-strand breaks (DSBs) and replication stress. Reanalyzing multiomic data from breast, ovarian, endometrial, and colon cancers, we confirmed correlations between LINE-1 expression, p53 mutation status, and CNA. We observed a consistent correlation between LINE-1 expression and the abundance of DNA replication complex components, indicating that LINE-1 may also induce replication stress in human tumors. In endometrial cancer, high-quality phosphoproteomic data allowed us to identify the DSB-induced ATM-MRN-SMC S phase checkpoint pathway as the primary DNA damage response (DDR) pathway associated with LINE-1 expression. Induction of LINE-1 expression in an in vitro model led to increased phosphorylation of MRN complex member RAD50, suggesting that LINE-1 directly activates this pathway."xsd:string |
| http://purl.uniprot.org/citations/35169076 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.2115999119"xsd:string |
| http://purl.uniprot.org/citations/35169076 | http://purl.uniprot.org/core/author | "Cao S."xsd:string |
| http://purl.uniprot.org/citations/35169076 | http://purl.uniprot.org/core/author | "Ding L."xsd:string |
| http://purl.uniprot.org/citations/35169076 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/35169076 | http://purl.uniprot.org/core/author | "Boeke J.D."xsd:string |
| http://purl.uniprot.org/citations/35169076 | http://purl.uniprot.org/core/author | "LaCava J."xsd:string |
| http://purl.uniprot.org/citations/35169076 | http://purl.uniprot.org/core/author | "Burns K.H."xsd:string |
| http://purl.uniprot.org/citations/35169076 | http://purl.uniprot.org/core/author | "Fenyo D."xsd:string |
| http://purl.uniprot.org/citations/35169076 | http://purl.uniprot.org/core/author | "Mendez-Dorantes C."xsd:string |
| http://purl.uniprot.org/citations/35169076 | http://purl.uniprot.org/core/author | "Mita P."xsd:string |
| http://purl.uniprot.org/citations/35169076 | http://purl.uniprot.org/core/author | "Grivainis M."xsd:string |
| http://purl.uniprot.org/citations/35169076 | http://purl.uniprot.org/core/author | "McKerrow W."xsd:string |
| http://purl.uniprot.org/citations/35169076 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35169076 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/35169076 | http://purl.uniprot.org/core/pages | "e2115999119"xsd:string |
| http://purl.uniprot.org/citations/35169076 | http://purl.uniprot.org/core/title | "LINE-1 expression in cancer correlates with p53 mutation, copy number alteration, and S phase checkpoint."xsd:string |
| http://purl.uniprot.org/citations/35169076 | http://purl.uniprot.org/core/volume | "119"xsd:string |
| http://purl.uniprot.org/citations/35169076 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35169076 |
| http://purl.uniprot.org/citations/35169076 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35169076 |
| http://purl.uniprot.org/uniprot/#_Q5T7N2-mappedCitation-35169076 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35169076 |
| http://purl.uniprot.org/uniprot/Q5T7N2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/35169076 |