| http://purl.uniprot.org/citations/35175311 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35175311 | http://www.w3.org/2000/01/rdf-schema#comment | "Iodide (I-) is crucial to thyroid function, and its regulation in thyrocytes involves ion transporters and reactive oxygen species (ROS). However, the extent of 2Cl-/H+ exchanger (ClC-3) involvement in the iodide (I-) efflux from thyrocytes remains unclear. Therefore, we examined the effects of ClC-3 on I-efflux. ClC-3 expression was found to significantly alter the serum TT3 and TT4 concentrations in mice. We further found that excess I-stimulation affected ClC-3 expression, distribution, and I-efflux in FRTL-5 cells. Immunofluorescence analyses indicated that ClC-3 mainly accumulated in the cell membrane and co-localized with β-tubulins after 24 h of excess I-treatment, and that this process depended on ROS production. Thus, ClC-3 may be involved in I-efflux at the apical pole of thyrocytes via excess I--induced ROS production and β-tubulin polymerization. Our results reveal novel insights into the role of ClC-3 in I- transport and thyroid function."xsd:string |
| http://purl.uniprot.org/citations/35175311 | http://purl.org/dc/terms/identifier | "doi:10.1042/bcj20210709"xsd:string |
| http://purl.uniprot.org/citations/35175311 | http://purl.uniprot.org/core/author | "Chen L."xsd:string |
| http://purl.uniprot.org/citations/35175311 | http://purl.uniprot.org/core/author | "Deng Z."xsd:string |
| http://purl.uniprot.org/citations/35175311 | http://purl.uniprot.org/core/author | "Wei Y."xsd:string |
| http://purl.uniprot.org/citations/35175311 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/35175311 | http://purl.uniprot.org/core/author | "Zhu L."xsd:string |
| http://purl.uniprot.org/citations/35175311 | http://purl.uniprot.org/core/author | "Wang P."xsd:string |
| http://purl.uniprot.org/citations/35175311 | http://purl.uniprot.org/core/author | "Yu M."xsd:string |
| http://purl.uniprot.org/citations/35175311 | http://purl.uniprot.org/core/author | "Mao J."xsd:string |
| http://purl.uniprot.org/citations/35175311 | http://purl.uniprot.org/core/author | "Peng S."xsd:string |
| http://purl.uniprot.org/citations/35175311 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35175311 | http://purl.uniprot.org/core/name | "Biochem J"xsd:string |
| http://purl.uniprot.org/citations/35175311 | http://purl.uniprot.org/core/pages | "629-640"xsd:string |
| http://purl.uniprot.org/citations/35175311 | http://purl.uniprot.org/core/title | "Excess iodide-induced reactive oxygen species elicit iodide efflux via beta-tubulin-associated ClC-3 in thyrocytes."xsd:string |
| http://purl.uniprot.org/citations/35175311 | http://purl.uniprot.org/core/volume | "479"xsd:string |
| http://purl.uniprot.org/citations/35175311 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35175311 |
| http://purl.uniprot.org/citations/35175311 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35175311 |
| http://purl.uniprot.org/uniprot/#_A0A6Q6Q7B9-mappedCitation-35175311 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35175311 |
| http://purl.uniprot.org/uniprot/#_P51791-mappedCitation-35175311 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35175311 |
| http://purl.uniprot.org/uniprot/#_Q3TTK0-mappedCitation-35175311 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35175311 |
| http://purl.uniprot.org/uniprot/#_Q790S0-mappedCitation-35175311 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35175311 |
| http://purl.uniprot.org/uniprot/#_Q3UEX5-mappedCitation-35175311 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35175311 |
| http://purl.uniprot.org/uniprot/#_Q6PEV2-mappedCitation-35175311 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35175311 |