| http://purl.uniprot.org/citations/35188403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35188403 | http://www.w3.org/2000/01/rdf-schema#comment | "Laryngeal squamous cell carcinoma (LSCC) is the most common malignant tumor in the head and neck cancer, with a poor prognosis. As we know, microRNAs (miRNAs) play a vital role in the initiation and development of various cancers including LSCC. In this study, we explored the role of miR-125b-5p and its downstream regulatory pathway in LSCC. Our data demonstrated that miR-125b-5p expression was significantly downregulated in LSCC tissues and cells. LSCC patients with high expression of miR-125b-5p had higher overall survival (OS) and were closely related to the clinical stage. Overexpression of miR-125b-5p impaired viability and glycolysis, and facilitated apoptosis in LSCC cells. And miR-125b-5p silencing had the opposite effects. Bioinformatics website predicted that MAP3K9 was one of the potential target genes of miR-125b-5p. Cell experiments demonstrated that miR-125b-5p repressed the MAP3K9 levels by directly targeting MAP3K9. Additionally, the negative correlation between miR-125b-5p and MAP3K9 was validated in LSCC tissues. Overexpression of MAP3K9 attenuated the inhibitory effect of miR-125b-5p on viability and glycolysis, and the pro-apoptosis effect of miR-125b-5p in LSCC cells. Furthermore, in vivo experiments demonstrated that tumor growth was hampered in AMC-HN-8 cells transfected with miR-125b-5p mimic. In contrast, the knockdown of miR-125b-5p reduced tumor growth in vivo. Meanwhile, the in vivo immunohistochemistry and TUNEL assays suggested that the miR-125b-5p overexpression restrained cell proliferation and promoted apoptosis via targeting MAP3K9. Overall, these above results suggested that miR-125b-5p suppressed proliferation and glycolysis, and promoted apoptosis by directly targeting MAP3K9 in LSCC cells. Thus, miR-125b-5p acts as a tumor suppressor miRNA and the miR-125b-5p/MAP3K9 axis may be a promising candidate for LSCC treatment."xsd:string |
| http://purl.uniprot.org/citations/35188403 | http://purl.org/dc/terms/identifier | "doi:10.4149/neo_2022_211027n1532"xsd:string |
| http://purl.uniprot.org/citations/35188403 | http://purl.uniprot.org/core/author | "Chen F."xsd:string |
| http://purl.uniprot.org/citations/35188403 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/35188403 | http://purl.uniprot.org/core/author | "Wang S.Z."xsd:string |
| http://purl.uniprot.org/citations/35188403 | http://purl.uniprot.org/core/author | "Zhang H.Y."xsd:string |
| http://purl.uniprot.org/citations/35188403 | http://purl.uniprot.org/core/author | "Lao Z."xsd:string |
| http://purl.uniprot.org/citations/35188403 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35188403 | http://purl.uniprot.org/core/name | "Neoplasma"xsd:string |
| http://purl.uniprot.org/citations/35188403 | http://purl.uniprot.org/core/pages | "550-559"xsd:string |
| http://purl.uniprot.org/citations/35188403 | http://purl.uniprot.org/core/title | "Elevation of miR-125b-5p is related to improved prognosis in laryngeal squamous cell carcinoma and inhibits the malignancy and glycometabolic disorder by targeting MAP3K9."xsd:string |
| http://purl.uniprot.org/citations/35188403 | http://purl.uniprot.org/core/volume | "69"xsd:string |
| http://purl.uniprot.org/citations/35188403 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35188403 |
| http://purl.uniprot.org/citations/35188403 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35188403 |
| http://purl.uniprot.org/uniprot/#_B3KRI5-mappedCitation-35188403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35188403 |
| http://purl.uniprot.org/uniprot/#_B4DGF4-mappedCitation-35188403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35188403 |
| http://purl.uniprot.org/uniprot/#_B4DSG3-mappedCitation-35188403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35188403 |
| http://purl.uniprot.org/uniprot/#_B4DZC4-mappedCitation-35188403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35188403 |
| http://purl.uniprot.org/uniprot/#_G3V347-mappedCitation-35188403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35188403 |
| http://purl.uniprot.org/uniprot/#_J3KPI6-mappedCitation-35188403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35188403 |
| http://purl.uniprot.org/uniprot/#_P80192-mappedCitation-35188403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35188403 |
| http://purl.uniprot.org/uniprot/#_Q8NEB1-mappedCitation-35188403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35188403 |
| http://purl.uniprot.org/uniprot/G3V347 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/35188403 |
| http://purl.uniprot.org/uniprot/B4DGF4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/35188403 |