| http://purl.uniprot.org/citations/35192689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35192689 | http://www.w3.org/2000/01/rdf-schema#comment | "Finding therapies that can protect and expand functional β-cell mass is a major goal of diabetes research. Here, we generated β-cell-specific conditional knockout and gain-of-function mouse models and used human islet transplant experiments to examine how manipulating Nrf2 levels affects β-cell survival, proliferation, and mass. Depletion of Nrf2 in β-cells results in decreased glucose-stimulated β-cell proliferation ex vivo and decreased adaptive β-cell proliferation and β-cell mass expansion after a high-fat diet in vivo. Nrf2 protects β-cells from apoptosis after a high-fat diet. Nrf2 loss of function decreases Pdx1 abundance and insulin content. Activating Nrf2 in a β-cell-specific manner increases β-cell proliferation and mass and improves glucose tolerance. Human islets transplanted under the kidney capsule of immunocompromised mice and treated systemically with bardoxolone methyl, an Nrf2 activator, display increased β-cell proliferation. Thus, by managing reactive oxygen species levels, Nrf2 regulates β-cell mass and is an exciting therapeutic target for expanding and protecting β-cell mass in diabetes."xsd:string |
| http://purl.uniprot.org/citations/35192689 | http://purl.org/dc/terms/identifier | "doi:10.2337/db21-0581"xsd:string |
| http://purl.uniprot.org/citations/35192689 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/35192689 | http://purl.uniprot.org/core/author | "Katz L.S."xsd:string |
| http://purl.uniprot.org/citations/35192689 | http://purl.uniprot.org/core/author | "Scott D.K."xsd:string |
| http://purl.uniprot.org/citations/35192689 | http://purl.uniprot.org/core/author | "Biswal S."xsd:string |
| http://purl.uniprot.org/citations/35192689 | http://purl.uniprot.org/core/author | "Garcia-Ocana A."xsd:string |
| http://purl.uniprot.org/citations/35192689 | http://purl.uniprot.org/core/author | "Baumel-Alterzon S."xsd:string |
| http://purl.uniprot.org/citations/35192689 | http://purl.uniprot.org/core/author | "Brill G."xsd:string |
| http://purl.uniprot.org/citations/35192689 | http://purl.uniprot.org/core/author | "Jean-Pierre C."xsd:string |
| http://purl.uniprot.org/citations/35192689 | http://purl.uniprot.org/core/author | "Tse I."xsd:string |
| http://purl.uniprot.org/citations/35192689 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35192689 | http://purl.uniprot.org/core/name | "Diabetes"xsd:string |
| http://purl.uniprot.org/citations/35192689 | http://purl.uniprot.org/core/pages | "989-1011"xsd:string |
| http://purl.uniprot.org/citations/35192689 | http://purl.uniprot.org/core/title | "Nrf2 Regulates beta-Cell Mass by Suppressing beta-Cell Death and Promoting beta-Cell Proliferation."xsd:string |
| http://purl.uniprot.org/citations/35192689 | http://purl.uniprot.org/core/volume | "71"xsd:string |
| http://purl.uniprot.org/citations/35192689 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35192689 |
| http://purl.uniprot.org/citations/35192689 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35192689 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SS10-mappedCitation-35192689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35192689 |
| http://purl.uniprot.org/uniprot/#_O89076-mappedCitation-35192689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35192689 |
| http://purl.uniprot.org/uniprot/#_Q05DM3-mappedCitation-35192689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35192689 |
| http://purl.uniprot.org/uniprot/#_Q05DU7-mappedCitation-35192689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35192689 |
| http://purl.uniprot.org/uniprot/#_Q3UWI4-mappedCitation-35192689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35192689 |
| http://purl.uniprot.org/uniprot/#_Q60795-mappedCitation-35192689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35192689 |