| http://purl.uniprot.org/citations/35210419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35210419 | http://www.w3.org/2000/01/rdf-schema#comment | "Following the decline of neurogenesis at birth, progenitors of the subventricular zone (SVZ) remain mostly in a quiescent state in the adult human brain. The mechanisms that regulate this quiescent state are still unclear. Here, we isolate CD271+ progenitors from the aged human SVZ for single-cell RNA sequencing analysis. Our transcriptome data reveal the identity of progenitors of the aged human SVZ as late oligodendrocyte progenitor cells. We identify the Wnt pathway antagonist SFRP1 as a possible signal that promotes quiescence of progenitors from the aged human SVZ. Administration of WAY-316606, a small molecule that inhibits SFRP1 function, stimulates activation of neural stem cells both in vitro and in vivo under homeostatic conditions. Our data unravel a possible mechanism through which progenitors of the adult human SVZ are maintained in a quiescent state and a potential target for stimulating progenitors to re-activate."xsd:string |
| http://purl.uniprot.org/citations/35210419 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-022-28626-9"xsd:string |
| http://purl.uniprot.org/citations/35210419 | http://purl.uniprot.org/core/author | "Wang C.C."xsd:string |
| http://purl.uniprot.org/citations/35210419 | http://purl.uniprot.org/core/author | "Pasterkamp R.J."xsd:string |
| http://purl.uniprot.org/citations/35210419 | http://purl.uniprot.org/core/author | "Hol E.M."xsd:string |
| http://purl.uniprot.org/citations/35210419 | http://purl.uniprot.org/core/author | "Sluijs J.A."xsd:string |
| http://purl.uniprot.org/citations/35210419 | http://purl.uniprot.org/core/author | "Basak O."xsd:string |
| http://purl.uniprot.org/citations/35210419 | http://purl.uniprot.org/core/author | "van Dijk R.E."xsd:string |
| http://purl.uniprot.org/citations/35210419 | http://purl.uniprot.org/core/author | "van der Geest A.T."xsd:string |
| http://purl.uniprot.org/citations/35210419 | http://purl.uniprot.org/core/author | "Donega V."xsd:string |
| http://purl.uniprot.org/citations/35210419 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35210419 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/35210419 | http://purl.uniprot.org/core/pages | "1036"xsd:string |
| http://purl.uniprot.org/citations/35210419 | http://purl.uniprot.org/core/title | "Single-cell profiling of human subventricular zone progenitors identifies SFRP1 as a target to re-activate progenitors."xsd:string |
| http://purl.uniprot.org/citations/35210419 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/35210419 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35210419 |
| http://purl.uniprot.org/citations/35210419 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35210419 |
| http://purl.uniprot.org/uniprot/#_A8KAM5-mappedCitation-35210419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35210419 |
| http://purl.uniprot.org/uniprot/#_P48432-mappedCitation-35210419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35210419 |
| http://purl.uniprot.org/uniprot/#_Q3V2B6-mappedCitation-35210419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35210419 |
| http://purl.uniprot.org/uniprot/#_Q8N474-mappedCitation-35210419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35210419 |
| http://purl.uniprot.org/uniprot/#_Q05DS5-mappedCitation-35210419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35210419 |
| http://purl.uniprot.org/uniprot/#_Q3UES8-mappedCitation-35210419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35210419 |
| http://purl.uniprot.org/uniprot/#_Q60I23-mappedCitation-35210419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35210419 |