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| http://purl.uniprot.org/citations/35226578 | http://www.w3.org/2000/01/rdf-schema#comment | "Macroautophagy/autophagy-related protein Atg8/LC3 is important for autophagosome biogenesis and required for selective degradation of various substrates. In our recent study, we performed a yeast two-hybrid screening to identify proteins that interact with Atg8a, the Drosophila homolog of Atg8/LC3. The screening identified several Atg8a-interacting proteins. These proteins include: i) proteins which have already been experimentally verified to bind Atg8a, such as Atg1, DOR, ref(2)P and key (Kenny); ii) proteins for which their mammalian homologs interact with Atg8-family members, like Ank2, Atg4, and Nedd4; and iii) several novel Atg8a-interacting proteins, such as trc/STK38 and Tak1. We showed that Tak1, as well as its co-activator, Tab2, both interact with Atg8a and are substrates for selective autophagic clearance. We also determined that SH3PX1 interacts with Tab2 and is necessary for the effective regulation of the immune-deficiency (IMD) pathway. Our findings suggest a mechanism for the regulatory interactions between Tak1-Tab2-SH3PX1 and Atg8a, which contribute to the fine-tuning of the IMD pathway."xsd:string |
| http://purl.uniprot.org/citations/35226578 | http://purl.org/dc/terms/identifier | "doi:10.1080/15548627.2022.2045535"xsd:string |
| http://purl.uniprot.org/citations/35226578 | http://purl.uniprot.org/core/author | "Nezis I.P."xsd:string |
| http://purl.uniprot.org/citations/35226578 | http://purl.uniprot.org/core/author | "Tsapras P."xsd:string |
| http://purl.uniprot.org/citations/35226578 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35226578 | http://purl.uniprot.org/core/name | "Autophagy"xsd:string |
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| http://purl.uniprot.org/citations/35226578 | http://purl.uniprot.org/core/title | "A yeast two-hybrid screening identifies novel Atg8a interactors in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/35226578 | http://purl.uniprot.org/core/volume | "18"xsd:string |
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