| http://purl.uniprot.org/citations/35227768 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35227768 | http://www.w3.org/2000/01/rdf-schema#comment | "The mechanisms underlying the regulation of neurogenesis in the adult brain remain unclear. Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a neurotrophic factor that has been implicated in various neuropathological processes and endoplasmic reticulum stress. However, the role of MANF in neurogenesis has not been investigated. Using a central nervous system (CNS)-specific Manf knock-out mouse model, we examined the role of MANF in mouse neurogenesis. We demonstrated that MANF deficiency increased BrdU labeling and Ki-67 positive cells in the subgranular zone and subventricular zone. MANF knock-out-induced upregulation of proliferative activity was accompanied by a decrease of cell cycle inhibitors (p15 and p27), an increase of G2/M marker (phospho-histone H3), as well as an increase of neural progenitor markers (Sox2 and NeuroD1) in the brain. In vitro studies using N2A neuroblastoma cells showed that the gain-of-function of MANF inhibited cell cycle progression, whereas the loss-of-function of MANF promoted cell cycle progression. Collectively, our findings indicate MANF deficiency affects cell proliferation and suggest a role of MANF in the neurogenesis of the adult brain."xsd:string |
| http://purl.uniprot.org/citations/35227768 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.brainresbull.2022.02.019"xsd:string |
| http://purl.uniprot.org/citations/35227768 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/35227768 | http://purl.uniprot.org/core/author | "Luo J."xsd:string |
| http://purl.uniprot.org/citations/35227768 | http://purl.uniprot.org/core/author | "Ma M."xsd:string |
| http://purl.uniprot.org/citations/35227768 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/35227768 | http://purl.uniprot.org/core/author | "Xu M."xsd:string |
| http://purl.uniprot.org/citations/35227768 | http://purl.uniprot.org/core/author | "Xu H."xsd:string |
| http://purl.uniprot.org/citations/35227768 | http://purl.uniprot.org/core/author | "Wen W."xsd:string |
| http://purl.uniprot.org/citations/35227768 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35227768 | http://purl.uniprot.org/core/name | "Brain Res Bull"xsd:string |
| http://purl.uniprot.org/citations/35227768 | http://purl.uniprot.org/core/pages | "49-56"xsd:string |
| http://purl.uniprot.org/citations/35227768 | http://purl.uniprot.org/core/title | "Deficiency of mesencephalic astrocyte-derived neurotrophic factor affects neurogenesis in mouse brain."xsd:string |
| http://purl.uniprot.org/citations/35227768 | http://purl.uniprot.org/core/volume | "183"xsd:string |
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