| http://purl.uniprot.org/citations/35233070 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35233070 | http://www.w3.org/2000/01/rdf-schema#comment | "Ryanodine receptor 2 (RyR2) is abundantly expressed in the heart and brain. Mutations in RyR2 are associated with both cardiac arrhythmias and intellectual disability. While the mechanisms of RyR2-linked arrhythmias are well characterized, little is known about the mechanism underlying RyR2-associated intellectual disability. Here, we employed a mouse model expressing a green fluorescent protein (GFP)-tagged RyR2 and a specific GFP probe to determine the subcellular localization of RyR2 in hippocampus. GFP-RyR2 was predominantly detected in the soma and dendrites, but not the dendritic spines of CA1 pyramidal neurons or dentate gyrus granular neurons. GFP-RyR2 was also detected within the mossy fibers in the stratum lucidum of CA3, but not in the presynaptic terminals of CA1 neurons. An arrhythmogenic RyR2-R4496C+/- mutation downregulated the A-type K+ current and increased membrane excitability, but had little effect on the afterhyperpolarization current or presynaptic facilitation of CA1 neurons. The RyR2-R4496C+/- mutation also impaired hippocampal long-term potentiation, learning, and memory. These data reveal the precise subcellular distribution of hippocampal RyR2 and its important role in neuronal excitability, learning, and memory."xsd:string |
| http://purl.uniprot.org/citations/35233070 | http://purl.org/dc/terms/identifier | "doi:10.1038/s42003-022-03124-2"xsd:string |
| http://purl.uniprot.org/citations/35233070 | http://purl.uniprot.org/core/author | "Chen L."xsd:string |
| http://purl.uniprot.org/citations/35233070 | http://purl.uniprot.org/core/author | "Huang J."xsd:string |
| http://purl.uniprot.org/citations/35233070 | http://purl.uniprot.org/core/author | "Sun B."xsd:string |
| http://purl.uniprot.org/citations/35233070 | http://purl.uniprot.org/core/author | "Song Z."xsd:string |
| http://purl.uniprot.org/citations/35233070 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/35233070 | http://purl.uniprot.org/core/author | "Wang R."xsd:string |
| http://purl.uniprot.org/citations/35233070 | http://purl.uniprot.org/core/author | "Ganguly A."xsd:string |
| http://purl.uniprot.org/citations/35233070 | http://purl.uniprot.org/core/author | "Yao J."xsd:string |
| http://purl.uniprot.org/citations/35233070 | http://purl.uniprot.org/core/author | "Zamponi G.W."xsd:string |
| http://purl.uniprot.org/citations/35233070 | http://purl.uniprot.org/core/author | "Chen S.R.W."xsd:string |
| http://purl.uniprot.org/citations/35233070 | http://purl.uniprot.org/core/author | "Institoris A."xsd:string |
| http://purl.uniprot.org/citations/35233070 | http://purl.uniprot.org/core/author | "Stys P.K."xsd:string |
| http://purl.uniprot.org/citations/35233070 | http://purl.uniprot.org/core/author | "Gordon G.R."xsd:string |
| http://purl.uniprot.org/citations/35233070 | http://purl.uniprot.org/core/author | "Hiess F."xsd:string |
| http://purl.uniprot.org/citations/35233070 | http://purl.uniprot.org/core/author | "Ter Keurs H.E.D.J."xsd:string |
| http://purl.uniprot.org/citations/35233070 | http://purl.uniprot.org/core/author | "Estillore J.P."xsd:string |
| http://purl.uniprot.org/citations/35233070 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35233070 | http://purl.uniprot.org/core/name | "Commun Biol"xsd:string |
| http://purl.uniprot.org/citations/35233070 | http://purl.uniprot.org/core/pages | "183"xsd:string |
| http://purl.uniprot.org/citations/35233070 | http://purl.uniprot.org/core/title | "Subcellular localization of hippocampal ryanodine receptor 2 and its role in neuronal excitability and memory."xsd:string |
| http://purl.uniprot.org/citations/35233070 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/35233070 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35233070 |