| http://purl.uniprot.org/citations/35235452 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35235452 | http://www.w3.org/2000/01/rdf-schema#comment | "SignificanceΔNp63 is a master regulator of skin homeostasis since it finely controls keratinocyte differentiation and proliferation. Here, we provide cellular and molecular evidence demonstrating the functional role of a ΔNp63 interactor, the R-loop-resolving enzyme Senataxin (SETX), in fine-tuning keratinocyte differentiation. We found that SETX physically binds the p63 DNA-binding motif present in two early epidermal differentiation genes, Keratin 1 (KRT1) and ZNF750, facilitating R-loop removal over their 3' ends and thus allowing efficient transcriptional termination and gene expression. These molecular events translate into the inability of SETX-depleted keratinocytes to undergo the correct epidermal differentiation program. Remarkably, SETX is dysregulated in cutaneous squamous cell carcinoma, suggesting its potential involvement in the pathogenesis of skin disorders."xsd:string |
| http://purl.uniprot.org/citations/35235452 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.2104718119"xsd:string |
| http://purl.uniprot.org/citations/35235452 | http://purl.uniprot.org/core/author | "De Nicola F."xsd:string |
| http://purl.uniprot.org/citations/35235452 | http://purl.uniprot.org/core/author | "Melino G."xsd:string |
| http://purl.uniprot.org/citations/35235452 | http://purl.uniprot.org/core/author | "Peschiaroli A."xsd:string |
| http://purl.uniprot.org/citations/35235452 | http://purl.uniprot.org/core/author | "Ricci F."xsd:string |
| http://purl.uniprot.org/citations/35235452 | http://purl.uniprot.org/core/author | "Mauriello A."xsd:string |
| http://purl.uniprot.org/citations/35235452 | http://purl.uniprot.org/core/author | "Gatti V."xsd:string |
| http://purl.uniprot.org/citations/35235452 | http://purl.uniprot.org/core/author | "Candi E."xsd:string |
| http://purl.uniprot.org/citations/35235452 | http://purl.uniprot.org/core/author | "Compagnone M."xsd:string |
| http://purl.uniprot.org/citations/35235452 | http://purl.uniprot.org/core/author | "Fierro C."xsd:string |
| http://purl.uniprot.org/citations/35235452 | http://purl.uniprot.org/core/author | "Fania L."xsd:string |
| http://purl.uniprot.org/citations/35235452 | http://purl.uniprot.org/core/author | "Scalera S."xsd:string |
| http://purl.uniprot.org/citations/35235452 | http://purl.uniprot.org/core/author | "Montanaro M."xsd:string |
| http://purl.uniprot.org/citations/35235452 | http://purl.uniprot.org/core/author | "La Banca V."xsd:string |
| http://purl.uniprot.org/citations/35235452 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35235452 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/35235452 | http://purl.uniprot.org/core/pages | "e2104718119"xsd:string |
| http://purl.uniprot.org/citations/35235452 | http://purl.uniprot.org/core/title | "DeltaNp63-Senataxin circuit controls keratinocyte differentiation by promoting the transcriptional termination of epidermal genes."xsd:string |
| http://purl.uniprot.org/citations/35235452 | http://purl.uniprot.org/core/volume | "119"xsd:string |
| http://purl.uniprot.org/citations/35235452 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35235452 |
| http://purl.uniprot.org/citations/35235452 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35235452 |
| http://purl.uniprot.org/uniprot/#_A0A141PNN3-mappedCitation-35235452 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35235452 |
| http://purl.uniprot.org/uniprot/#_A0A141PNN4-mappedCitation-35235452 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35235452 |