| http://purl.uniprot.org/citations/35235462 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35235462 | http://www.w3.org/2000/01/rdf-schema#comment | "Lymphocytic choriomeningitis virus (LCMV) is a rodent-borne zoonotic arenavirus that causes congenital abnormalities and can be fatal for transplant recipients. Using a genome-wide loss-of-function screen, we identify host factors required for LCMV entry into cells. We identify the lysosomal mucin CD164, glycosylation factors, the heparan sulfate biosynthesis machinery, and the known receptor alpha-dystroglycan (α-DG). Biochemical analysis revealed that the LCMV glycoprotein binds CD164 at acidic pH and requires a sialylated glycan at residue N104. We demonstrate that LCMV entry proceeds by the virus switching binding from heparan sulfate or α-DG at the plasma membrane to CD164 prior to membrane fusion, thus identifying additional potential targets for therapeutic intervention."xsd:string |
| http://purl.uniprot.org/citations/35235462 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.2119676119"xsd:string |
| http://purl.uniprot.org/citations/35235462 | http://purl.uniprot.org/core/author | "Brusic V."xsd:string |
| http://purl.uniprot.org/citations/35235462 | http://purl.uniprot.org/core/author | "Hastie K.M."xsd:string |
| http://purl.uniprot.org/citations/35235462 | http://purl.uniprot.org/core/author | "Whelan S.P.J."xsd:string |
| http://purl.uniprot.org/citations/35235462 | http://purl.uniprot.org/core/author | "Saphire E.O."xsd:string |
| http://purl.uniprot.org/citations/35235462 | http://purl.uniprot.org/core/author | "Stubbs S.H."xsd:string |
| http://purl.uniprot.org/citations/35235462 | http://purl.uniprot.org/core/author | "Moon-Walker A."xsd:string |
| http://purl.uniprot.org/citations/35235462 | http://purl.uniprot.org/core/author | "Bakkers M.J.G."xsd:string |
| http://purl.uniprot.org/citations/35235462 | http://purl.uniprot.org/core/author | "Herlo R."xsd:string |
| http://purl.uniprot.org/citations/35235462 | http://purl.uniprot.org/core/author | "Kirchhausen T.L."xsd:string |
| http://purl.uniprot.org/citations/35235462 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35235462 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/35235462 | http://purl.uniprot.org/core/pages | "e2119676119"xsd:string |
| http://purl.uniprot.org/citations/35235462 | http://purl.uniprot.org/core/title | "CD164 is a host factor for lymphocytic choriomeningitis virus entry."xsd:string |
| http://purl.uniprot.org/citations/35235462 | http://purl.uniprot.org/core/volume | "119"xsd:string |
| http://purl.uniprot.org/citations/35235462 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35235462 |
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