| http://purl.uniprot.org/citations/35235777 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35235777 | http://www.w3.org/2000/01/rdf-schema#comment | "The factors that promote T cell expansion are not fully known. Creatine is an abundant circulating metabolite that has recently been implicated in T cell function; however, its cell-autonomous role in immune-cell function is unknown. Here, we show that creatine supports cell-intrinsic CD8+ T cell homeostasis. We further identify creatine kinase B (CKB) as the creatine kinase isoenzyme that supports these T cell properties. Loss of the creatine transporter (Slc6a8) or Ckb results in compromised CD8+ T cell expansion in response to infection without influencing adenylate energy charge. Rather, loss of Slc6a8 or Ckb disrupts naive T cell homeostasis and weakens TCR-mediated activation of mechanistic target of rapamycin complex 1 (mTORC1) signaling required for CD8+ T cell expansion. These data demonstrate a cell-intrinsic role for creatine transport and creatine transphosphorylation, independent of their effects on global cellular energy charge, in supporting CD8+ T cell homeostasis and effector function."xsd:string |
| http://purl.uniprot.org/citations/35235777 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2022.110446"xsd:string |
| http://purl.uniprot.org/citations/35235777 | http://purl.uniprot.org/core/author | "Jones R.G."xsd:string |
| http://purl.uniprot.org/citations/35235777 | http://purl.uniprot.org/core/author | "Kazak L."xsd:string |
| http://purl.uniprot.org/citations/35235777 | http://purl.uniprot.org/core/author | "Samborska B."xsd:string |
| http://purl.uniprot.org/citations/35235777 | http://purl.uniprot.org/core/author | "Hussain M.F."xsd:string |
| http://purl.uniprot.org/citations/35235777 | http://purl.uniprot.org/core/author | "Rahbani J.F."xsd:string |
| http://purl.uniprot.org/citations/35235777 | http://purl.uniprot.org/core/author | "Ma E.H."xsd:string |
| http://purl.uniprot.org/citations/35235777 | http://purl.uniprot.org/core/author | "Roy D.G."xsd:string |
| http://purl.uniprot.org/citations/35235777 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35235777 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/35235777 | http://purl.uniprot.org/core/pages | "110446"xsd:string |
| http://purl.uniprot.org/citations/35235777 | http://purl.uniprot.org/core/title | "Creatine transport and creatine kinase activity is required for CD8pisup>+pi/sup> T cell immunity."xsd:string |
| http://purl.uniprot.org/citations/35235777 | http://purl.uniprot.org/core/volume | "38"xsd:string |
| http://purl.uniprot.org/citations/35235777 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35235777 |
| http://purl.uniprot.org/citations/35235777 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35235777 |
| http://purl.uniprot.org/uniprot/#_A0A023JDV8-mappedCitation-35235777 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35235777 |
| http://purl.uniprot.org/uniprot/#_E9Q151-mappedCitation-35235777 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35235777 |
| http://purl.uniprot.org/uniprot/#_E9Q6T2-mappedCitation-35235777 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35235777 |
| http://purl.uniprot.org/uniprot/#_A2ALM6-mappedCitation-35235777 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35235777 |
| http://purl.uniprot.org/uniprot/#_F7C668-mappedCitation-35235777 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35235777 |
| http://purl.uniprot.org/uniprot/#_B2LHN0-mappedCitation-35235777 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35235777 |
| http://purl.uniprot.org/uniprot/#_F6UKB4-mappedCitation-35235777 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35235777 |
| http://purl.uniprot.org/uniprot/#_Q04447-mappedCitation-35235777 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35235777 |