| http://purl.uniprot.org/citations/35235808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35235808 | http://www.w3.org/2000/01/rdf-schema#comment | "Gα13 transduces signals from G-protein-coupled receptors. While Gα13 functions as a tumor suppressor in lymphomas, it is not known whether Gα13 is pro-tumorigenic or tumor suppressive in genetically engineered mouse (GEM) models of epithelial cancers. Here, we show that loss of Gα13 in the Kras/Tp53 (KPC) GEM model promotes well-differentiated tumors and reduces survival. Mechanistically, tumors developing in KPC mice with Gα13 loss exhibit increased E-cadherin expression and mTOR signaling. Importantly, human pancreatic ductal adenocarcinoma (PDAC) tumors with low Gα13 expression also exhibit increased E-cadherin expression and mTOR signaling. Treatment with the mTOR inhibitor rapamycin decreases the growth of syngeneic KPC tumors with Gα13 loss by promoting cell death. This work establishes a tumor-suppressive role of Gα13 in pancreatic tumorigenesis in the KPC GEM model and suggests targeting mTOR in human PDAC tumors with Gα13 loss."xsd:string |
| http://purl.uniprot.org/citations/35235808 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2022.110441"xsd:string |
| http://purl.uniprot.org/citations/35235808 | http://purl.uniprot.org/core/author | "Shields M.A."xsd:string |
| http://purl.uniprot.org/citations/35235808 | http://purl.uniprot.org/core/author | "Munshi H.G."xsd:string |
| http://purl.uniprot.org/citations/35235808 | http://purl.uniprot.org/core/author | "Spaulding C."xsd:string |
| http://purl.uniprot.org/citations/35235808 | http://purl.uniprot.org/core/author | "Khalafalla M.G."xsd:string |
| http://purl.uniprot.org/citations/35235808 | http://purl.uniprot.org/core/author | "Pham T.N.D."xsd:string |
| http://purl.uniprot.org/citations/35235808 | http://purl.uniprot.org/core/author | "Metropulos A.E."xsd:string |
| http://purl.uniprot.org/citations/35235808 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35235808 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/35235808 | http://purl.uniprot.org/core/pages | "110441"xsd:string |
| http://purl.uniprot.org/citations/35235808 | http://purl.uniprot.org/core/title | "Galpha13 loss in Kras/Tp53 mouse model of pancreatic tumorigenesis promotes tumors susceptible to rapamycin."xsd:string |
| http://purl.uniprot.org/citations/35235808 | http://purl.uniprot.org/core/volume | "38"xsd:string |
| http://purl.uniprot.org/citations/35235808 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35235808 |
| http://purl.uniprot.org/citations/35235808 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35235808 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SVY1-mappedCitation-35235808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35235808 |
| http://purl.uniprot.org/uniprot/#_Q0VDV7-mappedCitation-35235808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35235808 |
| http://purl.uniprot.org/uniprot/#_A0A158SIS7-mappedCitation-35235808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35235808 |
| http://purl.uniprot.org/uniprot/#_A0A5Q0MU23-mappedCitation-35235808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35235808 |
| http://purl.uniprot.org/uniprot/#_B2KGV5-mappedCitation-35235808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35235808 |
| http://purl.uniprot.org/uniprot/#_E9Q8V2-mappedCitation-35235808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35235808 |
| http://purl.uniprot.org/uniprot/#_P02340-mappedCitation-35235808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35235808 |
| http://purl.uniprot.org/uniprot/#_I7HIK9-mappedCitation-35235808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35235808 |
| http://purl.uniprot.org/uniprot/#_Q91XH8-mappedCitation-35235808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35235808 |