| http://purl.uniprot.org/citations/35237831 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35237831 | http://www.w3.org/2000/01/rdf-schema#comment | "Mammalian oocytes are arrested at meiotic prophase I. The dual-specificity phosphatase CDC25B is essential for cyclin-dependent kinase 1 (CDK1) activation that drives resumption of meiosis. CDC25B reverses the inhibitory effect of the protein kinases WEE1 and MYT1 on CDK1 activation. Cdc25b-/-female mice are infertile because oocytes cannot activate CDK1. To identify a role for CDC25B following resumption of meiosis, we restored CDK1 activation in Cdc25b-/-oocytes by inhibiting WEE1 and MYT1, or expressing EGFP-CDC25A or constitutively active EGFP-CDK1 from microinjected complementary RNAs. Forced CDK1 activation in Cdc25b-/-oocytes allowed resumption of meiosis, but oocytes mostly arrested at metaphase I (MI) with intact spindles. Similarly, approximately a third of Cdc25b+/-oocytes with a reduced amount of CDC25B arrested in MI. MI-arrested Cdc25b-/-oocytes also displayed a transient decrease in CDK1 activity similar to Cdc25b+/+ oocytes during the MI-MII transition, whereas Cdc25b+/-oocytes exhibited only a partial anaphase-promoting complex/cyclosome activation and anaphase I entry. Thus, CDC25B is necessary for the resumption of meiosis and the MI-MII transition."xsd:string |
| http://purl.uniprot.org/citations/35237831 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.252924"xsd:string |
| http://purl.uniprot.org/citations/35237831 | http://purl.uniprot.org/core/author | "Schultz R.M."xsd:string |
| http://purl.uniprot.org/citations/35237831 | http://purl.uniprot.org/core/author | "Macurek L."xsd:string |
| http://purl.uniprot.org/citations/35237831 | http://purl.uniprot.org/core/author | "Solc P."xsd:string |
| http://purl.uniprot.org/citations/35237831 | http://purl.uniprot.org/core/author | "Ferencova I."xsd:string |
| http://purl.uniprot.org/citations/35237831 | http://purl.uniprot.org/core/author | "Drutovic D."xsd:string |
| http://purl.uniprot.org/citations/35237831 | http://purl.uniprot.org/core/author | "Knoblochova L."xsd:string |
| http://purl.uniprot.org/citations/35237831 | http://purl.uniprot.org/core/author | "Vaskovicova M."xsd:string |
| http://purl.uniprot.org/citations/35237831 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35237831 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/35237831 | http://purl.uniprot.org/core/pages | "jcs252924"xsd:string |
| http://purl.uniprot.org/citations/35237831 | http://purl.uniprot.org/core/title | "CDC25B is required for the metaphase I-metaphase II transition in mouse oocytes."xsd:string |
| http://purl.uniprot.org/citations/35237831 | http://purl.uniprot.org/core/volume | "135"xsd:string |
| http://purl.uniprot.org/citations/35237831 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35237831 |
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