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http://purl.uniprot.org/citations/3524673http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/3524673http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/3524673http://www.w3.org/2000/01/rdf-schema#comment"The complete amino acid sequence of human von Willebrand factor (vWF) is presented. Most of the sequence was determined by analysis of the S-carboxymethylated protein. Some overlaps not provided by the protein sequence analysis were obtained from the sequence predicted by the nucleotide sequence of a cDNA clone [Sadler, J.E., Shelton-Inloes, B.B., Sorace, J., Harlan, M., Titani, K., & Davie, E.W. (1985) Proc. Natl. Acad. Sci. U.S.A. 82, 6391-6398]. The protein is composed of 2050 amino acid residues containing 12 Asn-linked and 10 Thr/Ser-linked oligosaccharide chains. One of the carbohydrate chains is linked to an Asn residue in the sequence Asn-Ser-Cys rather than the usual Asn-X-Ser/Thr sequence. The sequence of von Willebrand factor includes several regions bearing evidence of internal gene duplication of ancestral sequences. The protein also contains the tetrapeptide sequence Arg-Gly-Asp-Ser (at residues 1744-1747), which may be a cell attachment site, as in fibronectin. The amino- and carboxyl-terminal regions of the molecule contain clusters of half-cystinyl residues. The sequence is unique except for some homology to human complement factor B."xsd:string
http://purl.uniprot.org/citations/3524673http://purl.org/dc/terms/identifier"doi:10.1021/bi00359a015"xsd:string
http://purl.uniprot.org/citations/3524673http://purl.org/dc/terms/identifier"doi:10.1021/bi00359a015"xsd:string
http://purl.uniprot.org/citations/3524673http://purl.uniprot.org/core/author"Kumar S."xsd:string
http://purl.uniprot.org/citations/3524673http://purl.uniprot.org/core/author"Kumar S."xsd:string
http://purl.uniprot.org/citations/3524673http://purl.uniprot.org/core/author"Walsh K.A."xsd:string
http://purl.uniprot.org/citations/3524673http://purl.uniprot.org/core/author"Walsh K.A."xsd:string
http://purl.uniprot.org/citations/3524673http://purl.uniprot.org/core/author"Fujikawa K."xsd:string
http://purl.uniprot.org/citations/3524673http://purl.uniprot.org/core/author"Fujikawa K."xsd:string
http://purl.uniprot.org/citations/3524673http://purl.uniprot.org/core/author"Titani K."xsd:string
http://purl.uniprot.org/citations/3524673http://purl.uniprot.org/core/author"Titani K."xsd:string
http://purl.uniprot.org/citations/3524673http://purl.uniprot.org/core/author"Takio K."xsd:string
http://purl.uniprot.org/citations/3524673http://purl.uniprot.org/core/author"Takio K."xsd:string
http://purl.uniprot.org/citations/3524673http://purl.uniprot.org/core/author"Ericsson L.H."xsd:string
http://purl.uniprot.org/citations/3524673http://purl.uniprot.org/core/author"Ericsson L.H."xsd:string
http://purl.uniprot.org/citations/3524673http://purl.uniprot.org/core/author"Sadler J.E."xsd:string
http://purl.uniprot.org/citations/3524673http://purl.uniprot.org/core/author"Sadler J.E."xsd:string
http://purl.uniprot.org/citations/3524673http://purl.uniprot.org/core/author"Wade R.D."xsd:string
http://purl.uniprot.org/citations/3524673http://purl.uniprot.org/core/author"Wade R.D."xsd:string
http://purl.uniprot.org/citations/3524673http://purl.uniprot.org/core/author"Ashida K."xsd:string
http://purl.uniprot.org/citations/3524673http://purl.uniprot.org/core/author"Ashida K."xsd:string
http://purl.uniprot.org/citations/3524673http://purl.uniprot.org/core/author"Chopek M.W."xsd:string
http://purl.uniprot.org/citations/3524673http://purl.uniprot.org/core/author"Chopek M.W."xsd:string