| http://purl.uniprot.org/citations/3525527 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/3525527 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/3525527 | http://www.w3.org/2000/01/rdf-schema#comment | "Apolipoprotein C-II plays a major role in lipid metabolism as a cofactor for lipoprotein lipase, the enzyme involved in the hydrolysis of triglyceride-rich lipoproteins. Apo-C-II is initially synthesized as a 101 amino acid protein that undergoes subsequent cotranslational cleavage of a signal peptide. Post-translational processing of apo-C-II has not been previously described. In this manuscript we identify four major plasma isoforms of apo-C-II by two-dimensional gel electrophoresis and immunoblot analysis that result from post-translational modification of apo-C-II. Neuraminidase studies have shown that two of these isoforms are early secreted sialic acid containing glycoproteins. Amino acid compositional and amino-terminal analysis have established that the major plasma isoform of apo-C-II is proapo-C-II. Proapo-C-II undergoes proteolytic cleavage of its amino-terminal hexapeptide to generate the mature form of apo-C-II. Thus, apo-C-II appears to be secreted as a carbohydrate containing proprotein that then undergoes deglycosylation and proteolytic cleavage to generate mature apo-C-II, a minor isoform in plasma. An improved understanding of the structural relationship of the various plasma isoforms of apo-C-II will help to elucidate the mechanisms involved in normal, as well as defective, processing of apo-C-II."xsd:string |
| http://purl.uniprot.org/citations/3525527 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(18)67554-4"xsd:string |
| http://purl.uniprot.org/citations/3525527 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(18)67554-4"xsd:string |
| http://purl.uniprot.org/citations/3525527 | http://purl.uniprot.org/core/author | "Brewer H.B. Jr."xsd:string |
| http://purl.uniprot.org/citations/3525527 | http://purl.uniprot.org/core/author | "Brewer H.B. Jr."xsd:string |
| http://purl.uniprot.org/citations/3525527 | http://purl.uniprot.org/core/author | "Fairwell T."xsd:string |
| http://purl.uniprot.org/citations/3525527 | http://purl.uniprot.org/core/author | "Fairwell T."xsd:string |
| http://purl.uniprot.org/citations/3525527 | http://purl.uniprot.org/core/author | "Hoeg J.M."xsd:string |
| http://purl.uniprot.org/citations/3525527 | http://purl.uniprot.org/core/author | "Hoeg J.M."xsd:string |
| http://purl.uniprot.org/citations/3525527 | http://purl.uniprot.org/core/author | "Meng M.S."xsd:string |
| http://purl.uniprot.org/citations/3525527 | http://purl.uniprot.org/core/author | "Meng M.S."xsd:string |
| http://purl.uniprot.org/citations/3525527 | http://purl.uniprot.org/core/author | "Ronan R."xsd:string |
| http://purl.uniprot.org/citations/3525527 | http://purl.uniprot.org/core/author | "Ronan R."xsd:string |
| http://purl.uniprot.org/citations/3525527 | http://purl.uniprot.org/core/author | "Bishop C."xsd:string |
| http://purl.uniprot.org/citations/3525527 | http://purl.uniprot.org/core/author | "Bishop C."xsd:string |
| http://purl.uniprot.org/citations/3525527 | http://purl.uniprot.org/core/author | "Fojo S.S."xsd:string |
| http://purl.uniprot.org/citations/3525527 | http://purl.uniprot.org/core/author | "Fojo S.S."xsd:string |
| http://purl.uniprot.org/citations/3525527 | http://purl.uniprot.org/core/author | "Sprecher D.L."xsd:string |
| http://purl.uniprot.org/citations/3525527 | http://purl.uniprot.org/core/author | "Sprecher D.L."xsd:string |
| http://purl.uniprot.org/citations/3525527 | http://purl.uniprot.org/core/author | "Taam L."xsd:string |
| http://purl.uniprot.org/citations/3525527 | http://purl.uniprot.org/core/author | "Taam L."xsd:string |
| http://purl.uniprot.org/citations/3525527 | http://purl.uniprot.org/core/date | "1986"xsd:gYear |
| http://purl.uniprot.org/citations/3525527 | http://purl.uniprot.org/core/date | "1986"xsd:gYear |