| http://purl.uniprot.org/citations/35271300 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35271300 | http://www.w3.org/2000/01/rdf-schema#comment | "Cytokines signal through cell surface receptor dimers to initiate activation of intracellular Janus kinases (JAKs). We report the 3.6-angstrom-resolution cryo-electron microscopy structure of full-length JAK1 complexed with a cytokine receptor intracellular domain Box1 and Box2 regions captured as an activated homodimer bearing the valine→phenylalanine (VF) mutation prevalent in myeloproliferative neoplasms. The seven domains of JAK1 form an extended structural unit, the dimerization of which is mediated by close-packing of the pseudokinase (PK) domains from the monomeric subunits. The oncogenic VF mutation lies within the core of the JAK1 PK interdimer interface, enhancing packing complementarity to facilitate ligand-independent activation. The carboxy-terminal tyrosine kinase domains are poised for transactivation and to phosphorylate the receptor STAT (signal transducer and activator of transcription)-recruiting motifs projecting from the overhanging FERM (four-point-one, ezrin, radixin, moesin)-SH2 (Src homology 2)-domains. Mapping of constitutively active JAK mutants supports a two-step allosteric activation mechanism and reveals opportunities for selective therapeutic targeting of oncogenic JAK signaling."xsd:string |
| http://purl.uniprot.org/citations/35271300 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.abn8933"xsd:string |
| http://purl.uniprot.org/citations/35271300 | http://purl.uniprot.org/core/author | "Garcia K.C."xsd:string |
| http://purl.uniprot.org/citations/35271300 | http://purl.uniprot.org/core/author | "Tsutsumi N."xsd:string |
| http://purl.uniprot.org/citations/35271300 | http://purl.uniprot.org/core/author | "Jude K.M."xsd:string |
| http://purl.uniprot.org/citations/35271300 | http://purl.uniprot.org/core/author | "Saxton R.A."xsd:string |
| http://purl.uniprot.org/citations/35271300 | http://purl.uniprot.org/core/author | "Lupardus P.J."xsd:string |
| http://purl.uniprot.org/citations/35271300 | http://purl.uniprot.org/core/author | "Glassman C.R."xsd:string |
| http://purl.uniprot.org/citations/35271300 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35271300 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/35271300 | http://purl.uniprot.org/core/pages | "163-169"xsd:string |
| http://purl.uniprot.org/citations/35271300 | http://purl.uniprot.org/core/title | "Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation."xsd:string |
| http://purl.uniprot.org/citations/35271300 | http://purl.uniprot.org/core/volume | "376"xsd:string |
| http://purl.uniprot.org/citations/35271300 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35271300 |
| http://purl.uniprot.org/citations/35271300 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35271300 |
| http://purl.uniprot.org/uniprot/#_P52332-mappedCitation-35271300 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35271300 |
| http://purl.uniprot.org/uniprot/#_Q8CGK5-mappedCitation-35271300 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35271300 |
| http://purl.uniprot.org/uniprot/P52332 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/35271300 |
| http://purl.uniprot.org/uniprot/Q8CGK5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/35271300 |