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http://purl.uniprot.org/citations/35274492http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/35274492http://www.w3.org/2000/01/rdf-schema#comment"

Background

Melanoma is an aggressive disease that is rising in incidence. Advanced melanoma is still a life-threatening disease. CircRNAs are documented to be involved in melanoma progression. But circITCH role in melanoma remains unclear.

Methods and results

To explore the functions of circITCH in melanoma, levels of circITCH in melanoma tissues and paracarcinoma normal tissues were detected. To study the roles of circITCH in melanoma in terms of cell proliferation and migration, in vitro and in vivo experiments were performed. Mechanism study was designed to investigate the potential regulatory effect of circITCH in melanoma. Results revealed that circITCH expression was repressed in melanoma versus adjacent normal tissues. Function study showed that circITCH suppressed melanoma cell proliferation and metastasis. The mechanism study showed that circITCH-sponged miR-660 to upregulate TFCP2 and suppress melanoma progression.

Conclusions

The circITCH/miR-660/TFCP2 axis is involved in melanoma progression hence circITCH can be a diagnostic biomarker as well as a target for treating melanoma."xsd:string
http://purl.uniprot.org/citations/35274492http://purl.org/dc/terms/identifier"doi:10.1002/cam4.4627"xsd:string
http://purl.uniprot.org/citations/35274492http://purl.uniprot.org/core/author"Cai Y."xsd:string
http://purl.uniprot.org/citations/35274492http://purl.uniprot.org/core/author"Jiang B."xsd:string
http://purl.uniprot.org/citations/35274492http://purl.uniprot.org/core/author"Zhang J."xsd:string
http://purl.uniprot.org/citations/35274492http://purl.uniprot.org/core/author"Zhao C."xsd:string
http://purl.uniprot.org/citations/35274492http://purl.uniprot.org/core/author"Sheng S."xsd:string
http://purl.uniprot.org/citations/35274492http://purl.uniprot.org/core/date"2022"xsd:gYear
http://purl.uniprot.org/citations/35274492http://purl.uniprot.org/core/name"Cancer Med"xsd:string
http://purl.uniprot.org/citations/35274492http://purl.uniprot.org/core/pages"2405-2413"xsd:string
http://purl.uniprot.org/citations/35274492http://purl.uniprot.org/core/title"circITCH suppresses cell proliferation and metastasis through miR-660/TFCP2 pathway in melanoma."xsd:string
http://purl.uniprot.org/citations/35274492http://purl.uniprot.org/core/volume"11"xsd:string
http://purl.uniprot.org/citations/35274492http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/35274492
http://purl.uniprot.org/citations/35274492http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/35274492
http://purl.uniprot.org/uniprot/#_Q12800-mappedCitation-35274492http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/35274492
http://purl.uniprot.org/uniprot/Q12800http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/35274492