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| http://purl.uniprot.org/citations/35274968 | http://www.w3.org/2000/01/rdf-schema#comment | "Homologous recombination (HR) is an essential meiotic process that contributes to the genetic variation of offspring and ensures accurate chromosome segregation. Recombination is facilitated by the formation and repair of programmed DNA double-strand breaks. These DNA breaks are repaired via recombination between maternal and paternal homologous chromosomes and a subset result in the formation of crossovers. HR and crossover formation is facilitated by synapsis of homologous chromosomes by a proteinaceous scaffold structure known as the synaptonemal complex (SC). Recent studies in yeast and worms have indicated that polo-like kinases (PLKs) regulate several events during meiosis, including DNA recombination and SC dynamics. Mammals express four active PLKs (PLK1-4), and our previous work assessing localization and kinase function in mouse spermatocytes suggested that PLK1 coordinates nuclear events during meiotic prophase. Therefore, we conditionally mutated Plk1 in early prophase spermatocytes and assessed stages of HR, crossover formation, and SC processes. Plk1 mutation resulted in increased RPA foci and reduced RAD51/DMC1 foci during zygonema, and an increase of both class I and class II crossover events. Furthermore, the disassembly of SC lateral elements was aberrant. Our results highlight the importance of PLK1 in regulating HR and SC disassembly during spermatogenesis."xsd:string |
| http://purl.uniprot.org/citations/35274968 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e21-03-0115"xsd:string |
| http://purl.uniprot.org/citations/35274968 | http://purl.uniprot.org/core/author | "Zhao X."xsd:string |
| http://purl.uniprot.org/citations/35274968 | http://purl.uniprot.org/core/author | "Jordan P.W."xsd:string |
| http://purl.uniprot.org/citations/35274968 | http://purl.uniprot.org/core/author | "Skinner M.W."xsd:string |
| http://purl.uniprot.org/citations/35274968 | http://purl.uniprot.org/core/author | "Shults C."xsd:string |
| http://purl.uniprot.org/citations/35274968 | http://purl.uniprot.org/core/author | "Wellard S.R."xsd:string |
| http://purl.uniprot.org/citations/35274968 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35274968 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/35274968 | http://purl.uniprot.org/core/pages | "ar37"xsd:string |
| http://purl.uniprot.org/citations/35274968 | http://purl.uniprot.org/core/title | "PLK1 depletion alters homologous recombination and synaptonemal complex disassembly events during mammalian spermatogenesis."xsd:string |
| http://purl.uniprot.org/citations/35274968 | http://purl.uniprot.org/core/volume | "33"xsd:string |
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