| http://purl.uniprot.org/citations/35292331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35292331 | http://www.w3.org/2000/01/rdf-schema#comment | "The medial habenula (mHb), a subregion of the habenula, is involved in diverse brain functions, such as nicotine addiction, anxiety, and anhedonia. We recently reported that TMEM16A deficiency, a calcium-activated chloride channel, decreased the activity of mHb cholinergic neurons. Since downregulated activity in cholinergic neurons of the mHb is involved in anhedonia-like behavior, we here investigated whether conditional deletion of TMEM16A in mHb cholinergic neurons also displays anhedonia-like behavior. The conditional deletion of TMEM16A in the mHb cholinergic neurons of mice (TMEM16A cKO mice) was generated by crossing ChaT-Cre (+) with floxed TMEM16A f/f mice. TMEM16A cKO mice displayed significantly reduced social interaction, sucrose preference, female urine sniffing, and increased marble burying. These behavioral data suggest the potential role of TMEM16A in anhedonic-like behavior in mice. Taken together, the presented data suggest that TMEM16A-mediated mHb activity might be a therapeutic target for anhedonia-related symptoms."xsd:string |
| http://purl.uniprot.org/citations/35292331 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbr.2022.113841"xsd:string |
| http://purl.uniprot.org/citations/35292331 | http://purl.uniprot.org/core/author | "Park J.Y."xsd:string |
| http://purl.uniprot.org/citations/35292331 | http://purl.uniprot.org/core/author | "Kim H.W."xsd:string |
| http://purl.uniprot.org/citations/35292331 | http://purl.uniprot.org/core/author | "Kwon O."xsd:string |
| http://purl.uniprot.org/citations/35292331 | http://purl.uniprot.org/core/author | "Hwang E.M."xsd:string |
| http://purl.uniprot.org/citations/35292331 | http://purl.uniprot.org/core/author | "Song J.G."xsd:string |
| http://purl.uniprot.org/citations/35292331 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35292331 | http://purl.uniprot.org/core/name | "Behav Brain Res"xsd:string |
| http://purl.uniprot.org/citations/35292331 | http://purl.uniprot.org/core/pages | "113841"xsd:string |
| http://purl.uniprot.org/citations/35292331 | http://purl.uniprot.org/core/title | "Conditional deletion of TMEM16A in cholinergic neurons of the medial habenula induces anhedonic-like behavior in mice."xsd:string |
| http://purl.uniprot.org/citations/35292331 | http://purl.uniprot.org/core/volume | "426"xsd:string |
| http://purl.uniprot.org/citations/35292331 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35292331 |
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