| http://purl.uniprot.org/citations/35294885 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35294885 | http://www.w3.org/2000/01/rdf-schema#comment | "The mechanisms coupling fate specification of distinct tissues to their physical separation remain to be understood. The trachea and esophagus differentiate from a single tube of definitive endoderm, requiring the transcription factors SOX2 and NKX2-1, but how the dorsoventral site of tissue separation is defined to allocate tracheal and esophageal cell types is unknown. Here, we show that the EPH/EPHRIN signaling gene Efnb2 regulates tracheoesophageal separation by controlling the dorsoventral allocation of tracheal-fated cells. Ventral loss of NKX2-1 results in disruption of separation and expansion of Efnb2 expression in the trachea independent of SOX2. Through chromatin immunoprecipitation and reporter assays, we find that NKX2-1 likely represses Efnb2 directly. Lineage tracing shows that loss of NKX2-1 results in misallocation of ventral foregut cells into the esophagus, while mosaicism for Nkx2-1 generates ectopic NKX2-1/EPHRIN-B2 boundaries that organize ectopic tracheal separation. Together, these data demonstrate that NKX2-1 coordinates tracheal specification with tissue separation through the regulation of EPHRIN-B2 and tracheoesophageal cell sorting."xsd:string |
| http://purl.uniprot.org/citations/35294885 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2022.110510"xsd:string |
| http://purl.uniprot.org/citations/35294885 | http://purl.uniprot.org/core/author | "Kuwahara A."xsd:string |
| http://purl.uniprot.org/citations/35294885 | http://purl.uniprot.org/core/author | "Lewis A.E."xsd:string |
| http://purl.uniprot.org/citations/35294885 | http://purl.uniprot.org/core/author | "Bush J.O."xsd:string |
| http://purl.uniprot.org/citations/35294885 | http://purl.uniprot.org/core/author | "Franzosi J."xsd:string |
| http://purl.uniprot.org/citations/35294885 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35294885 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/35294885 | http://purl.uniprot.org/core/pages | "110510"xsd:string |
| http://purl.uniprot.org/citations/35294885 | http://purl.uniprot.org/core/title | "Tracheal separation is driven by NKX2-1-mediated repression of Efnb2 and regulation of endodermal cell sorting."xsd:string |
| http://purl.uniprot.org/citations/35294885 | http://purl.uniprot.org/core/volume | "38"xsd:string |
| http://purl.uniprot.org/citations/35294885 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35294885 |
| http://purl.uniprot.org/citations/35294885 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35294885 |
| http://purl.uniprot.org/uniprot/#_D3Z7A6-mappedCitation-35294885 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35294885 |
| http://purl.uniprot.org/uniprot/#_A0A087WQW6-mappedCitation-35294885 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35294885 |
| http://purl.uniprot.org/uniprot/#_A0A087WQZ6-mappedCitation-35294885 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35294885 |
| http://purl.uniprot.org/uniprot/#_A0A087WRH4-mappedCitation-35294885 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35294885 |
| http://purl.uniprot.org/uniprot/#_E0CYA3-mappedCitation-35294885 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35294885 |
| http://purl.uniprot.org/uniprot/#_E9Q5I3-mappedCitation-35294885 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35294885 |
| http://purl.uniprot.org/uniprot/#_P52793-mappedCitation-35294885 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35294885 |
| http://purl.uniprot.org/uniprot/#_P52800-mappedCitation-35294885 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35294885 |
| http://purl.uniprot.org/uniprot/#_A0A0R4IZW5-mappedCitation-35294885 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35294885 |
| http://purl.uniprot.org/uniprot/#_A0A494B983-mappedCitation-35294885 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35294885 |
| http://purl.uniprot.org/uniprot/#_A0A338P6E0-mappedCitation-35294885 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35294885 |