Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/35301267http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/35301267http://www.w3.org/2000/01/rdf-schema#comment"

Background

A positive family history (PFH) of spondyloarthritis (SpA) consists of five SpA-related entities, of which a PFH of axial spondyloarthritis (axSpA) is most common in European patients with axSpA. Moreover, a PFH of axSpA is associated with human leucocyte antigen B27 (HLA-B27) positivity in these patients. It is unknown if this holds true in patients with axSpA in other parts of the world.

Objective

To investigate the geographical prevalence of a PFH of SpA and its association with HLA-B27 positivity in patients with axSpA worldwide.

Methods

Cross-sectional analyses included patients from the ASAS peripheral involvement in Spondyloarthritis (PerSpA) study from 24 countries worldwide with an axSpA diagnosis, known HLA-B27 status and family history. Logistic regression models were built to assess the effect of HLA-B27 status on the occurrence of PFH. This was repeated for each of the five SpA entities in a PFH.

Results

Among 2048 patients, axSpA was the most common SpA entity in a PFH in all geographical regions (Asia 28%, Europe and North America 27%, Latin America 20%, Middle East and North Africa 41%). A PFH of axSpA was associated with HLA-B27 positivity in Asia (OR 4.19), Europe and North America (OR 2.09) and Latin America (OR 3.95), but not in the Middle East and North Africa (OR 0.98), which has a lower prevalence of HLA-B27 positivity. A PFH of other SpA entities was less prevalent and not consistently associated with HLA-B27 positivity.

Conclusion

In patients with axSpA worldwide, axSpA was consistently the most common SpA entity in a family history and was associated with HLA-B27 positivity in all geographical regions but one."xsd:string
http://purl.uniprot.org/citations/35301267http://purl.org/dc/terms/identifier"doi:10.1136/rmdopen-2021-002174"xsd:string
http://purl.uniprot.org/citations/35301267http://purl.uniprot.org/core/author"Sieper J."xsd:string
http://purl.uniprot.org/citations/35301267http://purl.uniprot.org/core/author"Boel A."xsd:string
http://purl.uniprot.org/citations/35301267http://purl.uniprot.org/core/author"van Gaalen F.A."xsd:string
http://purl.uniprot.org/citations/35301267http://purl.uniprot.org/core/author"van der Heijde D."xsd:string
http://purl.uniprot.org/citations/35301267http://purl.uniprot.org/core/author"Lopez-Medina C."xsd:string
http://purl.uniprot.org/citations/35301267http://purl.uniprot.org/core/author"van Lunteren M."xsd:string
http://purl.uniprot.org/citations/35301267http://purl.uniprot.org/core/date"2022"xsd:gYear
http://purl.uniprot.org/citations/35301267http://purl.uniprot.org/core/name"RMD Open"xsd:string
http://purl.uniprot.org/citations/35301267http://purl.uniprot.org/core/pages"e002174"xsd:string
http://purl.uniprot.org/citations/35301267http://purl.uniprot.org/core/title"Geographical prevalence of family history in patients with axial spondyloarthritis and its association with HLA-B27 in the ASAS-PerSpA study."xsd:string
http://purl.uniprot.org/citations/35301267http://purl.uniprot.org/core/volume"8"xsd:string
http://purl.uniprot.org/citations/35301267http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/35301267
http://purl.uniprot.org/citations/35301267http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/35301267
http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-35301267http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/35301267
http://purl.uniprot.org/uniprot/#_A0A0E3DC98-mappedCitation-35301267http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/35301267
http://purl.uniprot.org/uniprot/#_A0A0E3DCA0-mappedCitation-35301267http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/35301267
http://purl.uniprot.org/uniprot/#_A0A0E3DCA1-mappedCitation-35301267http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/35301267
http://purl.uniprot.org/uniprot/#_A0A068B107-mappedCitation-35301267http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/35301267
http://purl.uniprot.org/uniprot/#_A0A068B112-mappedCitation-35301267http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/35301267
http://purl.uniprot.org/uniprot/#_A0A068B116-mappedCitation-35301267http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/35301267
http://purl.uniprot.org/uniprot/#_A0A068B2J5-mappedCitation-35301267http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/35301267
http://purl.uniprot.org/uniprot/#_A0A068B2Z1-mappedCitation-35301267http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/35301267
▶