| http://purl.uniprot.org/citations/35304452 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35304452 | http://www.w3.org/2000/01/rdf-schema#comment | "The epigenetic patterns that are established during early thymic development might determine mature T cell physiology and function, but the molecular basis and topography of the genetic elements involved are not fully known. Here we show, using the Cd4 locus as a paradigm for early developmental programming, that DNA demethylation during thymic development licenses a novel stimulus-responsive element that is critical for the maintenance of Cd4 gene expression in effector T cells. We document the importance of maintaining high CD4 expression during parasitic infection and show that by driving transcription, this stimulus-responsive element allows for the maintenance of histone H3K4me3 levels during T cell replication, which is critical for preventing de novo DNA methylation at the Cd4 promoter. A failure to undergo epigenetic programming during development leads to gene silencing during effector T cell replication. Our study thus provides evidence of early developmental events shaping the functional fitness of mature effector T cells."xsd:string |
| http://purl.uniprot.org/citations/35304452 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-022-28914-4"xsd:string |
| http://purl.uniprot.org/citations/35304452 | http://purl.uniprot.org/core/author | "Au C."xsd:string |
| http://purl.uniprot.org/citations/35304452 | http://purl.uniprot.org/core/author | "Littman D.R."xsd:string |
| http://purl.uniprot.org/citations/35304452 | http://purl.uniprot.org/core/author | "Maretzky T."xsd:string |
| http://purl.uniprot.org/citations/35304452 | http://purl.uniprot.org/core/author | "Gurung P."xsd:string |
| http://purl.uniprot.org/citations/35304452 | http://purl.uniprot.org/core/author | "Day K."xsd:string |
| http://purl.uniprot.org/citations/35304452 | http://purl.uniprot.org/core/author | "Yi R."xsd:string |
| http://purl.uniprot.org/citations/35304452 | http://purl.uniprot.org/core/author | "Keen H.L."xsd:string |
| http://purl.uniprot.org/citations/35304452 | http://purl.uniprot.org/core/author | "Teghanemt A."xsd:string |
| http://purl.uniprot.org/citations/35304452 | http://purl.uniprot.org/core/author | "Issuree P.D."xsd:string |
| http://purl.uniprot.org/citations/35304452 | http://purl.uniprot.org/core/author | "Yorek M.S."xsd:string |
| http://purl.uniprot.org/citations/35304452 | http://purl.uniprot.org/core/author | "Pulipati P."xsd:string |
| http://purl.uniprot.org/citations/35304452 | http://purl.uniprot.org/core/author | "Misel-Wuchter K."xsd:string |
| http://purl.uniprot.org/citations/35304452 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35304452 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/35304452 | http://purl.uniprot.org/core/pages | "1477"xsd:string |
| http://purl.uniprot.org/citations/35304452 | http://purl.uniprot.org/core/title | "CD4 expression in effector T cells depends on DNA demethylation over a developmentally established stimulus-responsive element."xsd:string |
| http://purl.uniprot.org/citations/35304452 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/35304452 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35304452 |
| http://purl.uniprot.org/citations/35304452 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35304452 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JG87-mappedCitation-35304452 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35304452 |
| http://purl.uniprot.org/uniprot/#_D0VLQ5-mappedCitation-35304452 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35304452 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGM1-mappedCitation-35304452 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35304452 |