| http://purl.uniprot.org/citations/35347148 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35347148 | http://www.w3.org/2000/01/rdf-schema#comment | "Carbohydrates, proteins and lipids are essential nutrients to all animals; however, closely related species, populations, and individuals can display dramatic variation in diet. Here we explore the variation in macronutrient tolerance in Drosophila melanogaster using the Drosophila genetic reference panel, a collection of ~200 strains derived from a single natural population. Our study demonstrates that D. melanogaster, often considered a "dietary generalist", displays marked genetic variation in survival on different diets, notably on high-sugar diet. Our genetic analysis and functional validation identify several regulators of macronutrient tolerance, including CG10960/GLUT8, Pkn and Eip75B. We also demonstrate a role for the JNK pathway in sugar tolerance and de novo lipogenesis. Finally, we report a role for tailless, a conserved orphan nuclear hormone receptor, in regulating sugar metabolism via insulin-like peptide secretion and sugar-responsive CCHamide-2 expression. Our study provides support for the use of nutrigenomics in the development of personalized nutrition."xsd:string |
| http://purl.uniprot.org/citations/35347148 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-022-29183-x"xsd:string |
| http://purl.uniprot.org/citations/35347148 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/35347148 | http://purl.uniprot.org/core/author | "Hasygar K."xsd:string |
| http://purl.uniprot.org/citations/35347148 | http://purl.uniprot.org/core/author | "Hietakangas V."xsd:string |
| http://purl.uniprot.org/citations/35347148 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/35347148 | http://purl.uniprot.org/core/author | "Francis D."xsd:string |
| http://purl.uniprot.org/citations/35347148 | http://purl.uniprot.org/core/author | "Neely G.G."xsd:string |
| http://purl.uniprot.org/citations/35347148 | http://purl.uniprot.org/core/author | "Clark T."xsd:string |
| http://purl.uniprot.org/citations/35347148 | http://purl.uniprot.org/core/author | "Simpson S.J."xsd:string |
| http://purl.uniprot.org/citations/35347148 | http://purl.uniprot.org/core/author | "Lamichane N."xsd:string |
| http://purl.uniprot.org/citations/35347148 | http://purl.uniprot.org/core/author | "Sylow L."xsd:string |
| http://purl.uniprot.org/citations/35347148 | http://purl.uniprot.org/core/author | "Ghazanfar S."xsd:string |
| http://purl.uniprot.org/citations/35347148 | http://purl.uniprot.org/core/author | "Johnstone J."xsd:string |
| http://purl.uniprot.org/citations/35347148 | http://purl.uniprot.org/core/author | "Senior A.M."xsd:string |
| http://purl.uniprot.org/citations/35347148 | http://purl.uniprot.org/core/author | "Mirth C."xsd:string |
| http://purl.uniprot.org/citations/35347148 | http://purl.uniprot.org/core/author | "Havula E."xsd:string |
| http://purl.uniprot.org/citations/35347148 | http://purl.uniprot.org/core/author | "Tong V."xsd:string |
| http://purl.uniprot.org/citations/35347148 | http://purl.uniprot.org/core/author | "Alves A.N."xsd:string |
| http://purl.uniprot.org/citations/35347148 | http://purl.uniprot.org/core/author | "Pulpitel T."xsd:string |
| http://purl.uniprot.org/citations/35347148 | http://purl.uniprot.org/core/author | "Needham E.J."xsd:string |
| http://purl.uniprot.org/citations/35347148 | http://purl.uniprot.org/core/author | "Alton L.A."xsd:string |
| http://purl.uniprot.org/citations/35347148 | http://purl.uniprot.org/core/author | "Audia G."xsd:string |
| http://purl.uniprot.org/citations/35347148 | http://purl.uniprot.org/core/author | "Jiwnani N."xsd:string |