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http://purl.uniprot.org/citations/3536126 | http://www.w3.org/2000/01/rdf-schema#comment | "We have devised a genetic selection for mutant yeast cells that fail to properly deliver the vacuolar glycoprotein CPY to the lysosome-like vacuole. This has allowed us to identify mutations in eight VPL complementation groups that result in aberrant secretion of up to approximately 90% of the immunoreactive CPY. Other soluble vacuolar proteins are also affected by each vpl mutation, demonstrating that a sorting system for multiple vacuolar proteins exists in yeast. Mislocalized CPY apparently traverses late stages of the secretory pathway, since a vesicle-accumulating sec1 mutation prevents secretion of this protein. Despite the presence of abnormal membrane-enclosed organelles in some of the vpl mutants, maturation and secretion of invertase are not substantially perturbed. Thus vpl mutations define a new class of genes that encode products required for sorting of newly synthesized vacuolar proteins from secretory proteins during their transit through the yeast secretory pathway."xsd:string |
http://purl.uniprot.org/citations/3536126 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(86)90819-6"xsd:string |
http://purl.uniprot.org/citations/3536126 | http://purl.uniprot.org/core/author | "Stevens T.H."xsd:string |
http://purl.uniprot.org/citations/3536126 | http://purl.uniprot.org/core/author | "Rothman J.H."xsd:string |
http://purl.uniprot.org/citations/3536126 | http://purl.uniprot.org/core/date | "1986"xsd:gYear |
http://purl.uniprot.org/citations/3536126 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
http://purl.uniprot.org/citations/3536126 | http://purl.uniprot.org/core/pages | "1041-1051"xsd:string |
http://purl.uniprot.org/citations/3536126 | http://purl.uniprot.org/core/title | "Protein sorting in yeast: mutants defective in vacuole biogenesis mislocalize vacuolar proteins into the late secretory pathway."xsd:string |
http://purl.uniprot.org/citations/3536126 | http://purl.uniprot.org/core/volume | "47"xsd:string |
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