| http://purl.uniprot.org/citations/35377797 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35377797 | http://www.w3.org/2000/01/rdf-schema#comment | "Enhancers integrate transcription factor signaling pathways that drive cell fate specification in the developing brain. We paired enhancer labeling and single-cell RNA-sequencing (scRNA-seq) to delineate and distinguish specification of neuronal lineages in mouse medial, lateral, and caudal ganglionic eminences (MGE, LGE, and CGE) at embryonic day (E)11.5. We show that scRNA-seq clustering using transcription factors improves resolution of regional and developmental populations, and that enhancer activities identify specific and overlapping GE-derived neuronal populations. First, we mapped the activities of seven evolutionarily conserved brain enhancers at single-cell resolution in vivo, finding that the selected enhancers had diverse activities in specific progenitor and neuronal populations across the GEs. We then applied enhancer-based labeling, scRNA-seq, and analysis of in situ hybridization data to distinguish transcriptionally distinct and spatially defined subtypes of MGE-derived GABAergic and cholinergic projection neurons and interneurons. Our results map developmental origins and specification paths underlying neurogenesis in the embryonic basal ganglia and showcase the power of scRNA-seq combined with enhancer-based labeling to resolve the complex paths of neuronal specification underlying mouse brain development."xsd:string |
| http://purl.uniprot.org/citations/35377797 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.2108760119"xsd:string |
| http://purl.uniprot.org/citations/35377797 | http://purl.uniprot.org/core/author | "Thompson C."xsd:string |
| http://purl.uniprot.org/citations/35377797 | http://purl.uniprot.org/core/author | "Zeng H."xsd:string |
| http://purl.uniprot.org/citations/35377797 | http://purl.uniprot.org/core/author | "Gartner Z.J."xsd:string |
| http://purl.uniprot.org/citations/35377797 | http://purl.uniprot.org/core/author | "Puelles L."xsd:string |
| http://purl.uniprot.org/citations/35377797 | http://purl.uniprot.org/core/author | "Nord A.S."xsd:string |
| http://purl.uniprot.org/citations/35377797 | http://purl.uniprot.org/core/author | "Rubenstein J.L.R."xsd:string |
| http://purl.uniprot.org/citations/35377797 | http://purl.uniprot.org/core/author | "Lim K.J."xsd:string |
| http://purl.uniprot.org/citations/35377797 | http://purl.uniprot.org/core/author | "McKinsey G.L."xsd:string |
| http://purl.uniprot.org/citations/35377797 | http://purl.uniprot.org/core/author | "Hawrylycz M.J."xsd:string |
| http://purl.uniprot.org/citations/35377797 | http://purl.uniprot.org/core/author | "Rubin A.N."xsd:string |
| http://purl.uniprot.org/citations/35377797 | http://purl.uniprot.org/core/author | "Ypsilanti A.R."xsd:string |
| http://purl.uniprot.org/citations/35377797 | http://purl.uniprot.org/core/author | "Silberberg S.N."xsd:string |
| http://purl.uniprot.org/citations/35377797 | http://purl.uniprot.org/core/author | "Su-Feher L."xsd:string |
| http://purl.uniprot.org/citations/35377797 | http://purl.uniprot.org/core/author | "Catta-Preta R."xsd:string |
| http://purl.uniprot.org/citations/35377797 | http://purl.uniprot.org/core/author | "Zdilar I."xsd:string |
| http://purl.uniprot.org/citations/35377797 | http://purl.uniprot.org/core/author | "McGinnis C.S."xsd:string |
| http://purl.uniprot.org/citations/35377797 | http://purl.uniprot.org/core/author | "Rubino T.E. Jr."xsd:string |
| http://purl.uniprot.org/citations/35377797 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35377797 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/35377797 | http://purl.uniprot.org/core/pages | "e2108760119"xsd:string |
| http://purl.uniprot.org/citations/35377797 | http://purl.uniprot.org/core/title | "Single cell enhancer activity distinguishes GABAergic and cholinergic lineages in embryonic mouse basal ganglia."xsd:string |
| http://purl.uniprot.org/citations/35377797 | http://purl.uniprot.org/core/volume | "119"xsd:string |