| http://purl.uniprot.org/citations/35379743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35379743 | http://www.w3.org/2000/01/rdf-schema#comment | "Unconventional HLA class I-restricted CD8+ T cell epitopes, longer than 10 aa, have been implicated to play a role in human immunity against viruses and cancer. T cell recognition of long peptides, centrally bulging from the HLA cleft, has been described previously. Alternatively, long peptides can contain a linear HLA-bound core peptide, with a N- or C-terminal peptide "tail" extending from the HLA peptide binding groove. The role of such a peptide "tail" in CD8+ T cell recognition remains unclear. In this study, we identified a 20mer peptide (FLPTPEELGLLGPPRPQVLA [FLP]) derived from the IL-27R subunit α gene restricted to HLA-A*02:01, for which we solved the crystal structure and demonstrated a long C-terminal "tail" extension. FLP-specific T cell clones demonstrated various recognition modes, some T cells recognized the FLP core peptide, while for other T cells the peptide tail was essential for recognition. These results demonstrate a crucial role for a C-terminal peptide tail in immunogenicity."xsd:string |
| http://purl.uniprot.org/citations/35379743 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.2101208"xsd:string |
| http://purl.uniprot.org/citations/35379743 | http://purl.uniprot.org/core/author | "van Veelen P.A."xsd:string |
| http://purl.uniprot.org/citations/35379743 | http://purl.uniprot.org/core/author | "Rossjohn J."xsd:string |
| http://purl.uniprot.org/citations/35379743 | http://purl.uniprot.org/core/author | "Gras S."xsd:string |
| http://purl.uniprot.org/citations/35379743 | http://purl.uniprot.org/core/author | "Falkenburg J.H.F."xsd:string |
| http://purl.uniprot.org/citations/35379743 | http://purl.uniprot.org/core/author | "de Ru A."xsd:string |
| http://purl.uniprot.org/citations/35379743 | http://purl.uniprot.org/core/author | "Heemskerk M.H.M."xsd:string |
| http://purl.uniprot.org/citations/35379743 | http://purl.uniprot.org/core/author | "Kester M.G.D."xsd:string |
| http://purl.uniprot.org/citations/35379743 | http://purl.uniprot.org/core/author | "Hagedoorn R.S."xsd:string |
| http://purl.uniprot.org/citations/35379743 | http://purl.uniprot.org/core/author | "van der Steen D.M."xsd:string |
| http://purl.uniprot.org/citations/35379743 | http://purl.uniprot.org/core/author | "Meeuwsen M.H."xsd:string |
| http://purl.uniprot.org/citations/35379743 | http://purl.uniprot.org/core/author | "Remst D.F.G."xsd:string |
| http://purl.uniprot.org/citations/35379743 | http://purl.uniprot.org/core/author | "Wouters A.K."xsd:string |
| http://purl.uniprot.org/citations/35379743 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35379743 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/35379743 | http://purl.uniprot.org/core/pages | "1851-1856"xsd:string |
| http://purl.uniprot.org/citations/35379743 | http://purl.uniprot.org/core/title | "Cutting Edge: Unconventional CD8+ T Cell Recognition of a Naturally Occurring HLA-A*02:01-Restricted 20mer Epitope."xsd:string |
| http://purl.uniprot.org/citations/35379743 | http://purl.uniprot.org/core/volume | "208"xsd:string |
| http://purl.uniprot.org/citations/35379743 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35379743 |
| http://purl.uniprot.org/citations/35379743 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35379743 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C543-mappedCitation-35379743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35379743 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C548-mappedCitation-35379743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35379743 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C551-mappedCitation-35379743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35379743 |