http://purl.uniprot.org/citations/35410390 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/35410390 | http://www.w3.org/2000/01/rdf-schema#comment | "IntroductionCD44 is a candidate gene for obesity and diabetes development and may be a critical mediator of a systemic inflammation associated with obesity and diabetes.MethodsWe investigated the relationship of CD44 with obesity in CD44-deficient mice challenged with a high-fat diet.ResultsIn mice fed a diet high in fat, cholesterol, and sucrose for 12 weeks fat mass accumulation was reduced in CD44-deficient mice bred onto both a C57BL/6J and the naturally TLR deficient C3H/HeJ background. Reduced fat mass could not be attributed to lower food intake or an increase in energy expenditure as measured by indirect calorimetry. However, we observed a 40-60% lower mRNA expression of the inflammation markers, F4/80, CD11b, TNF-α, and CD14, in adipose tissue of CD44-deficient mice on the C57BL/6J background but not the C3H/HeJ background, perhaps indicating that alternative factors may be affecting adiposity in this model. Measures of hepatic steatosis and insulin sensitivity were improved in CD44-deficient mice on a C57BL/6J but not in the C3H/HeJ mice. These results were highly sexually dimorphic as there were no detectable effects of CD44 inactivation in female mice on a C57BL/6 J or C3H/HeJ background.ConclusionCD44 was associated with adiposity, liver fat, and glucose in male mice. However, the effects of CD44 on obesity may be independent of TLR4 signaling."xsd:string |
http://purl.uniprot.org/citations/35410390 | http://purl.org/dc/terms/identifier | "doi:10.1186/s13293-022-00426-2"xsd:string |
http://purl.uniprot.org/citations/35410390 | http://purl.uniprot.org/core/author | "Kim M."xsd:string |
http://purl.uniprot.org/citations/35410390 | http://purl.uniprot.org/core/author | "Barron K."xsd:string |
http://purl.uniprot.org/citations/35410390 | http://purl.uniprot.org/core/author | "Bennett B.J."xsd:string |
http://purl.uniprot.org/citations/35410390 | http://purl.uniprot.org/core/author | "Albright J."xsd:string |
http://purl.uniprot.org/citations/35410390 | http://purl.uniprot.org/core/author | "VerHague M."xsd:string |
http://purl.uniprot.org/citations/35410390 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
http://purl.uniprot.org/citations/35410390 | http://purl.uniprot.org/core/name | "Biol Sex Differ"xsd:string |
http://purl.uniprot.org/citations/35410390 | http://purl.uniprot.org/core/pages | "14"xsd:string |
http://purl.uniprot.org/citations/35410390 | http://purl.uniprot.org/core/title | "Obesogenic and diabetic effects of CD44 in mice are sexually dimorphic and dependent on genetic background."xsd:string |
http://purl.uniprot.org/citations/35410390 | http://purl.uniprot.org/core/volume | "13"xsd:string |
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