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http://purl.uniprot.org/citations/35414117http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/35414117http://www.w3.org/2000/01/rdf-schema#comment"

Objective

LINC00114 could promote the development of colorectal cancer, but its mechanism has been rarely discussed in esophageal cancer (EC). Herein, we explored the molecular mechanism of LINC00114 via mediating enhancer of zeste homolog 2/deleted in liver cancer 1 (EZH2/DLC1) axis in EC.

Methods

LINC00114, EZH2 and DLC1 expression in EC tissues and cells were tested. LINC00114, EZH2 and DLC1 expression were altered in EC cells through transfection with different constructs, and cell proliferation, migration, invasion, apoptosis and glycolysis were subsequently observed. The interaction between LINC00114 and EZH2 and that between EZH2 and DLC1 were explored. Tumor formation was also conducted to confirm the in vitro results.

Results

The expression levels of LINC00114 and EZH2 were elevated while those of DLC1 were reduced in EC. Inhibiting LINC00114 or reducing EZH2 blocked cell proliferation, migration, invasion and glycolysis and induce cell apoptosis in EC. LINC00114 promoted H3K27 trimethylation of DLC1 by recruiting EZH2. Knockdown of DLC1 stimulated cell growth and glycolysis in EC and even mitigated the role of LINC00114 inhibition in EC. In vivo experiment further confirmed the anti-tumor effect of LINC00114 inhibition in EC.

Conclusion

The data indicate that LINC00114 promotes the development of EC by recruiting EZH2 to enhance H3K27me3 of DLC1."xsd:string
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http://purl.uniprot.org/citations/35414117http://purl.uniprot.org/core/author"Li Z."xsd:string
http://purl.uniprot.org/citations/35414117http://purl.uniprot.org/core/author"Li S."xsd:string
http://purl.uniprot.org/citations/35414117http://purl.uniprot.org/core/author"Li Y."xsd:string
http://purl.uniprot.org/citations/35414117http://purl.uniprot.org/core/author"Qin X."xsd:string
http://purl.uniprot.org/citations/35414117http://purl.uniprot.org/core/author"Zhou X."xsd:string
http://purl.uniprot.org/citations/35414117http://purl.uniprot.org/core/author"Qin J."xsd:string
http://purl.uniprot.org/citations/35414117http://purl.uniprot.org/core/author"Zhang H."xsd:string
http://purl.uniprot.org/citations/35414117http://purl.uniprot.org/core/date"2022"xsd:gYear
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http://purl.uniprot.org/citations/35414117http://purl.uniprot.org/core/pages"51"xsd:string
http://purl.uniprot.org/citations/35414117http://purl.uniprot.org/core/title"LINC00114 stimulates growth and glycolysis of esophageal cancer cells by recruiting EZH2 to enhance H3K27me3 of DLC1."xsd:string
http://purl.uniprot.org/citations/35414117http://purl.uniprot.org/core/volume"14"xsd:string
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