| http://purl.uniprot.org/citations/35420891 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35420891 | http://www.w3.org/2000/01/rdf-schema#comment | "Kinetochores assemble onto specialized centromeric CENP-A (centromere protein A) nucleosomes (CENP-ANuc) to mediate attachments between chromosomes and the mitotic spindle. We describe cryo-electron microscopy structures of the human inner kinetochore constitutive centromere associated network (CCAN) complex bound to CENP-ANuc reconstituted onto α-satellite DNA. CCAN forms edge-on contacts with CENP-ANuc, and a linker DNA segment of the α-satellite repeat emerges from the fully wrapped end of the nucleosome to thread through the central CENP-LN channel that tightly grips the DNA. The CENP-TWSX histone-fold module further augments DNA binding and partially wraps the linker DNA in a manner reminiscent of canonical nucleosomes. Our study suggests that the topological entrapment of the linker DNA by CCAN provides a robust mechanism by which kinetochores withstand both pushing and pulling forces exerted by the mitotic spindle."xsd:string |
| http://purl.uniprot.org/citations/35420891 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.abn3810"xsd:string |
| http://purl.uniprot.org/citations/35420891 | http://purl.uniprot.org/core/author | "Barford D."xsd:string |
| http://purl.uniprot.org/citations/35420891 | http://purl.uniprot.org/core/author | "McLaughlin S.H."xsd:string |
| http://purl.uniprot.org/citations/35420891 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/35420891 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/35420891 | http://purl.uniprot.org/core/author | "Bellini D."xsd:string |
| http://purl.uniprot.org/citations/35420891 | http://purl.uniprot.org/core/author | "Tischer T."xsd:string |
| http://purl.uniprot.org/citations/35420891 | http://purl.uniprot.org/core/author | "Dendooven T."xsd:string |
| http://purl.uniprot.org/citations/35420891 | http://purl.uniprot.org/core/author | "Muir K.W."xsd:string |
| http://purl.uniprot.org/citations/35420891 | http://purl.uniprot.org/core/author | "Yatskevich S."xsd:string |
| http://purl.uniprot.org/citations/35420891 | http://purl.uniprot.org/core/author | "Predin M."xsd:string |
| http://purl.uniprot.org/citations/35420891 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35420891 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/35420891 | http://purl.uniprot.org/core/pages | "844-852"xsd:string |
| http://purl.uniprot.org/citations/35420891 | http://purl.uniprot.org/core/title | "Structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome."xsd:string |
| http://purl.uniprot.org/citations/35420891 | http://purl.uniprot.org/core/volume | "376"xsd:string |
| http://purl.uniprot.org/citations/35420891 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35420891 |
| http://purl.uniprot.org/citations/35420891 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35420891 |
| http://purl.uniprot.org/uniprot/#_A8MT69-mappedCitation-35420891 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35420891 |
| http://purl.uniprot.org/uniprot/#_P62805-mappedCitation-35420891 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35420891 |
| http://purl.uniprot.org/uniprot/#_P62807-mappedCitation-35420891 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35420891 |
| http://purl.uniprot.org/uniprot/#_Q8N2Z9-mappedCitation-35420891 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35420891 |
| http://purl.uniprot.org/uniprot/#_Q03188-mappedCitation-35420891 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35420891 |