| http://purl.uniprot.org/citations/35422486 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35422486 | http://www.w3.org/2000/01/rdf-schema#comment | "In yeast, mitochondria are passed on to daughter cells via the actin cable, motor protein Myo2, and adaptor protein Mmr1. They are released from the actin-myosin machinery after reaching the daughter cells. We report that Mmr1 is rapidly degraded by the ubiquitin-proteasome system in Saccharomyces cerevisiae. Redundant ubiquitin ligases Dma1 and Dma2 are responsible for Mmr1 ubiquitination. Dma1/2-mediated Mmr1 ubiquitination requires phosphorylation, most likely at S414 residue by Ste20 and Cla4. These kinases are mostly localized to the growing bud and nearly absent from mother cells, ensuring phosphorylation and ubiquitination of Mmr1 after the mitochondria enter the growing bud. In dma1Δ dma2Δ cells, transported mitochondria are first stacked at the bud-tip and then pulled back to the bud-neck. Stacked mitochondria in dma1Δ dma2Δ cells exhibit abnormal morphology, elevated respiratory activity, and increased level of reactive oxygen species, along with hypersensitivity to oxidative stresses. Collectively, spatiotemporally-regulated Mmr1 turnover guarantees mitochondrial homeostasis."xsd:string |
| http://purl.uniprot.org/citations/35422486 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-022-29704-8"xsd:string |
| http://purl.uniprot.org/citations/35422486 | http://purl.uniprot.org/core/author | "Obara K."xsd:string |
| http://purl.uniprot.org/citations/35422486 | http://purl.uniprot.org/core/author | "Yoshikawa T."xsd:string |
| http://purl.uniprot.org/citations/35422486 | http://purl.uniprot.org/core/author | "Yamaguchi R."xsd:string |
| http://purl.uniprot.org/citations/35422486 | http://purl.uniprot.org/core/author | "Nishimura K."xsd:string |
| http://purl.uniprot.org/citations/35422486 | http://purl.uniprot.org/core/author | "Kamura T."xsd:string |
| http://purl.uniprot.org/citations/35422486 | http://purl.uniprot.org/core/author | "Nakatsukasa K."xsd:string |
| http://purl.uniprot.org/citations/35422486 | http://purl.uniprot.org/core/author | "Kuwata K."xsd:string |
| http://purl.uniprot.org/citations/35422486 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35422486 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/35422486 | http://purl.uniprot.org/core/pages | "2005"xsd:string |
| http://purl.uniprot.org/citations/35422486 | http://purl.uniprot.org/core/title | "Proteolysis of adaptor protein Mmr1 during budding is necessary for mitochondrial homeostasis in Saccharomyces cerevisiae."xsd:string |
| http://purl.uniprot.org/citations/35422486 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/35422486 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35422486 |
| http://purl.uniprot.org/citations/35422486 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35422486 |
| http://purl.uniprot.org/uniprot/#_A0A8H4F9X4-mappedCitation-35422486 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35422486 |
| http://purl.uniprot.org/uniprot/#_Q06324-mappedCitation-35422486 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35422486 |
| http://purl.uniprot.org/uniprot/A0A8H4F9X4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/35422486 |
| http://purl.uniprot.org/uniprot/Q06324 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/35422486 |