| http://purl.uniprot.org/citations/35428910 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35428910 | http://www.w3.org/2000/01/rdf-schema#comment | "Melanoma is responsible for 90% of skin cancer-related deaths. Major therapeutic advances have led to a considerable improvement in the prognosis of patients, with the development of targeted therapies (BRAF or MEK inhibitors) and immunotherapy (anti-CTLA-4 or -PD-1 antibodies). However, the tumor constitutes an immunosuppressive microenvironment that prevents the therapeutic efficacy and/or promotes the development of secondary resistances. CD160 is an activating NK-cell receptor initially described as delineating the NK and CD8+ T-cell cytotoxic populations. Three forms of CD160 have been described: (1) the GPI isoform, constitutively expressed and involved in the initiation of NK-cells' cytotoxic activity, (2) the transmembrane isoform, neo-synthesized upon cell activation, allowing the amplification of NK cells' cytotoxic functions and (3) the soluble form, generated after cleavage of the GPI isoform, which presents an immuno-suppressive activity. By performing immunohistochemistry analyses, we observed a strong expression of CD160 at the primary cutaneous tumor site of melanoma patients. We further demonstrated that melanoma cells express CD160-GPI isoform and constitutively release the soluble form (sCD160) into the tumor environment. sCD160 was shown to inhibit the cytotoxic activity of NK-cells towards their target cells. In addition, it was found in the serum of melanoma patients and associated with increased tumor dissemination. Altogether these results support a role for sCD160 in the mechanisms leading to the inhibition of anti-tumor response and immune surveillance in melanoma."xsd:string |
| http://purl.uniprot.org/citations/35428910 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00262-022-03199-0"xsd:string |
| http://purl.uniprot.org/citations/35428910 | http://purl.uniprot.org/core/author | "Lebbe C."xsd:string |
| http://purl.uniprot.org/citations/35428910 | http://purl.uniprot.org/core/author | "Bensussan A."xsd:string |
| http://purl.uniprot.org/citations/35428910 | http://purl.uniprot.org/core/author | "Giustiniani J."xsd:string |
| http://purl.uniprot.org/citations/35428910 | http://purl.uniprot.org/core/author | "Marie-Cardine A."xsd:string |
| http://purl.uniprot.org/citations/35428910 | http://purl.uniprot.org/core/author | "Foussat A."xsd:string |
| http://purl.uniprot.org/citations/35428910 | http://purl.uniprot.org/core/author | "Dumaz N."xsd:string |
| http://purl.uniprot.org/citations/35428910 | http://purl.uniprot.org/core/author | "Garbar C."xsd:string |
| http://purl.uniprot.org/citations/35428910 | http://purl.uniprot.org/core/author | "Thonnart N."xsd:string |
| http://purl.uniprot.org/citations/35428910 | http://purl.uniprot.org/core/author | "Lepelletier C."xsd:string |
| http://purl.uniprot.org/citations/35428910 | http://purl.uniprot.org/core/author | "Gauci M.L."xsd:string |
| http://purl.uniprot.org/citations/35428910 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35428910 | http://purl.uniprot.org/core/name | "Cancer Immunol Immunother"xsd:string |
| http://purl.uniprot.org/citations/35428910 | http://purl.uniprot.org/core/pages | "2731-2742"xsd:string |
| http://purl.uniprot.org/citations/35428910 | http://purl.uniprot.org/core/title | "The soluble form of CD160 acts as a tumor mediator of immune escape in melanoma."xsd:string |
| http://purl.uniprot.org/citations/35428910 | http://purl.uniprot.org/core/volume | "71"xsd:string |
| http://purl.uniprot.org/citations/35428910 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35428910 |
| http://purl.uniprot.org/citations/35428910 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35428910 |
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| http://purl.uniprot.org/uniprot/#_Q6FH89-mappedCitation-35428910 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35428910 |
| http://purl.uniprot.org/uniprot/O95971 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/35428910 |
| http://purl.uniprot.org/uniprot/Q6FH89 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/35428910 |