| http://purl.uniprot.org/citations/35434999 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35434999 | http://www.w3.org/2000/01/rdf-schema#comment | "Background We aimed to assess the association between number of pregnancies and long-term progression of cardiac dysfunction, arrhythmias, and event-free survival in women with pathogenic or likely pathogenic variants of gene encoding for Lamin A/C proteins ( LMNA+). Methods and Results We retrospectively included consecutive women with LMNA+ and recorded pregnancy data. We collected echocardiographic data, occurrence of atrial fibrillation, atrioventricular block, sustained ventricular arrhythmias, and implantation of cardiac electronic devices (implantable cardioverter defibrillator/cardiac resynchronization therapy defibrillator). We analyzed retrospectively complications during pregnancy and the peripartum period. We included 89 women with LMNA+ (28% probands, age 41±16 years), of which 60 had experienced pregnancy. Follow-up time was 5 [interquartile range, 3-9] years. We analyzed 452 repeated echocardiographic examinations. Number of pregnancies was not associated with increased long-term risk of atrial fibrillation, atrioventricular block, sustained ventricular arrhythmias, or implantable cardioverter defibrillator/cardiac resynchronization therapy defibrillator implantation. Women with previous pregnancy and nulliparous women had a similar annual deterioration of left ventricular ejection fraction (-0.5/year versus -0.3/year, P=0.37) and similar increase of left ventricular end-diastolic diameter (0.1/year versus 0.2/year, P=0.09). Number of pregnancies did not decrease survival free from death, left ventricular assist device, or need for cardiac transplantation. Arrhythmias occurred during 9% of pregnancies. No increase in maternal and fetal complications was observed. Conclusions In our cohort of women with LMNA+, pregnancy did not seem associated with long-term adverse disease progression or event-free survival. Likewise, women with LMNA+ generally well-tolerated pregnancy, with a small proportion of patients experiencing arrhythmias."xsd:string |
| http://purl.uniprot.org/citations/35434999 | http://purl.org/dc/terms/identifier | "doi:10.1161/jaha.121.024960"xsd:string |
| http://purl.uniprot.org/citations/35434999 | http://purl.uniprot.org/core/author | "Haugaa K.H."xsd:string |
| http://purl.uniprot.org/citations/35434999 | http://purl.uniprot.org/core/author | "Lakdawala N.K."xsd:string |
| http://purl.uniprot.org/citations/35434999 | http://purl.uniprot.org/core/author | "Edvardsen T."xsd:string |
| http://purl.uniprot.org/citations/35434999 | http://purl.uniprot.org/core/author | "Skulstad H."xsd:string |
| http://purl.uniprot.org/citations/35434999 | http://purl.uniprot.org/core/author | "Estensen M.E."xsd:string |
| http://purl.uniprot.org/citations/35434999 | http://purl.uniprot.org/core/author | "Lie O.H."xsd:string |
| http://purl.uniprot.org/citations/35434999 | http://purl.uniprot.org/core/author | "Castrini A.I."xsd:string |
| http://purl.uniprot.org/citations/35434999 | http://purl.uniprot.org/core/author | "Almaas V.M."xsd:string |
| http://purl.uniprot.org/citations/35434999 | http://purl.uniprot.org/core/author | "Lyseggen E."xsd:string |
| http://purl.uniprot.org/citations/35434999 | http://purl.uniprot.org/core/author | "Picard K.C.I."xsd:string |
| http://purl.uniprot.org/citations/35434999 | http://purl.uniprot.org/core/author | "Skjolsvik E."xsd:string |
| http://purl.uniprot.org/citations/35434999 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35434999 | http://purl.uniprot.org/core/name | "J Am Heart Assoc"xsd:string |
| http://purl.uniprot.org/citations/35434999 | http://purl.uniprot.org/core/pages | "e024960"xsd:string |
| http://purl.uniprot.org/citations/35434999 | http://purl.uniprot.org/core/title | "Pregnancy and Progression of Cardiomyopathy in Women With LMNA Genotype-Positive."xsd:string |
| http://purl.uniprot.org/citations/35434999 | http://purl.uniprot.org/core/volume | "11"xsd:string |
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| http://purl.uniprot.org/uniprot/#_A0A384MQX1-mappedCitation-35434999 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35434999 |
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| http://purl.uniprot.org/uniprot/#_Q8N519-mappedCitation-35434999 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35434999 |