| http://purl.uniprot.org/citations/35436657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35436657 | http://www.w3.org/2000/01/rdf-schema#comment | "Elicitation of the tumor-eliminating immune response is a major challenge, as macrophages- constituting a major component of solid tumor mass-play important roles in development, maintenance and tumor regression. The macrophage-expressed Toll-Like Receptors (TLRs) enhance macrophage function and their ability to activate T cells via secretion of cytokines, which may help in tumor regression. IL-27, a member of the IL-12 family of cytokines, is shown to exhibit anti-tumor and anti-angiogenic activities. Herein, we developed B16BL6 melanoma model in C75BL/6 mouse to dissect the crosstalk between TLRs and IL-27 in tumors. We report existence of a novel TLR-IL-27 feed-forward loop, whereby TLRs and IL-27 up-regulated each other's expression, which we found perturbed during melanoma tumorigenesis. Intra-tumoral injection of Imiquimod, a TLR7/8 ligand, reduced the tumor burden; the anti-tumor effect was reversed upon IL-27 and IL-27R silencing by intra-tumorally administered, lentivirally expressed IL-27 and IL-27R shRNA. The reduced tumor growth was accompanied by significantly fewer Treg cells but increased IFN-γ and granzyme B expression by CD8+ T cells. These data indicate the preventative role for TLR-induced IL-27 in aggressive and highly invasive melanoma."xsd:string |
| http://purl.uniprot.org/citations/35436657 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cyto.2022.155871"xsd:string |
| http://purl.uniprot.org/citations/35436657 | http://purl.uniprot.org/core/author | "Chattopadhyay D."xsd:string |
| http://purl.uniprot.org/citations/35436657 | http://purl.uniprot.org/core/author | "Pal C."xsd:string |
| http://purl.uniprot.org/citations/35436657 | http://purl.uniprot.org/core/author | "Bera S."xsd:string |
| http://purl.uniprot.org/citations/35436657 | http://purl.uniprot.org/core/author | "Roy K."xsd:string |
| http://purl.uniprot.org/citations/35436657 | http://purl.uniprot.org/core/author | "Saha B."xsd:string |
| http://purl.uniprot.org/citations/35436657 | http://purl.uniprot.org/core/author | "Dhar S."xsd:string |
| http://purl.uniprot.org/citations/35436657 | http://purl.uniprot.org/core/author | "Selvaraj S."xsd:string |
| http://purl.uniprot.org/citations/35436657 | http://purl.uniprot.org/core/author | "Patidar A."xsd:string |
| http://purl.uniprot.org/citations/35436657 | http://purl.uniprot.org/core/author | "Chakravarti M."xsd:string |
| http://purl.uniprot.org/citations/35436657 | http://purl.uniprot.org/core/author | "Baral R."xsd:string |
| http://purl.uniprot.org/citations/35436657 | http://purl.uniprot.org/core/author | "Bhuniya A."xsd:string |
| http://purl.uniprot.org/citations/35436657 | http://purl.uniprot.org/core/author | "Guha I."xsd:string |
| http://purl.uniprot.org/citations/35436657 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35436657 | http://purl.uniprot.org/core/name | "Cytokine"xsd:string |
| http://purl.uniprot.org/citations/35436657 | http://purl.uniprot.org/core/pages | "155871"xsd:string |
| http://purl.uniprot.org/citations/35436657 | http://purl.uniprot.org/core/title | "TLR induced IL-27 plays host-protective role against B16BL6 melanoma in C57BL/6 mice."xsd:string |
| http://purl.uniprot.org/citations/35436657 | http://purl.uniprot.org/core/volume | "154"xsd:string |
| http://purl.uniprot.org/citations/35436657 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35436657 |
| http://purl.uniprot.org/citations/35436657 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35436657 |
| http://purl.uniprot.org/uniprot/#_Q8K3I6-mappedCitation-35436657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35436657 |
| http://purl.uniprot.org/uniprot/Q8K3I6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/35436657 |