| http://purl.uniprot.org/citations/35440748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35440748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35440748 | http://www.w3.org/2000/01/rdf-schema#comment | "Previously, we have shown that the translocation of Grainyhead-like 3 (GRHL3) transcription factor from the nucleus to the cytoplasm triggers the switch from canonical Wnt signaling for epidermal differentiation to non-canonical Wnt signaling for epithelial morphogenesis. However, the molecular mechanism that underlies the cytoplasmic localization of GRHL3 protein and that activates non-canonical Wnt signaling is not known. Here, we show that ubiquitin-specific protease 39 (USP39), a deubiquitinating enzyme, is involved in the subcellular localization of GRHL3 as a potential GRHL3-interacting protein and is necessary for epithelial morphogenesis to up-regulate expression of planar cell polarity (PCP) components. Notably, mouse Usp39-deficient embryos display early embryonic lethality due to a failure in primitive streak formation and apico-basal polarity in epiblast cells, resembling those of mutant embryos of the Prickle1 gene, a crucial PCP component. Current findings provide unique insights into how differentiation and morphogenesis are coordinated to construct three-dimensional complex structures via USP39."xsd:string |
| http://purl.uniprot.org/citations/35440748 | http://purl.org/dc/terms/identifier | "doi:10.1038/s42003-022-03254-7"xsd:string |
| http://purl.uniprot.org/citations/35440748 | http://purl.org/dc/terms/identifier | "doi:10.1038/s42003-022-03254-7"xsd:string |
| http://purl.uniprot.org/citations/35440748 | http://purl.uniprot.org/core/author | "Mochida K."xsd:string |
| http://purl.uniprot.org/citations/35440748 | http://purl.uniprot.org/core/author | "Mochida K."xsd:string |
| http://purl.uniprot.org/citations/35440748 | http://purl.uniprot.org/core/author | "Matsuo I."xsd:string |
| http://purl.uniprot.org/citations/35440748 | http://purl.uniprot.org/core/author | "Matsuo I."xsd:string |
| http://purl.uniprot.org/citations/35440748 | http://purl.uniprot.org/core/author | "Kanno S.I."xsd:string |
| http://purl.uniprot.org/citations/35440748 | http://purl.uniprot.org/core/author | "Kanno S.I."xsd:string |
| http://purl.uniprot.org/citations/35440748 | http://purl.uniprot.org/core/author | "Kimura-Yoshida C."xsd:string |
| http://purl.uniprot.org/citations/35440748 | http://purl.uniprot.org/core/author | "Kimura-Yoshida C."xsd:string |
| http://purl.uniprot.org/citations/35440748 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35440748 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35440748 | http://purl.uniprot.org/core/name | "Commun. Biol."xsd:string |
| http://purl.uniprot.org/citations/35440748 | http://purl.uniprot.org/core/name | "Commun. Biol."xsd:string |
| http://purl.uniprot.org/citations/35440748 | http://purl.uniprot.org/core/pages | "378"xsd:string |
| http://purl.uniprot.org/citations/35440748 | http://purl.uniprot.org/core/pages | "378"xsd:string |
| http://purl.uniprot.org/citations/35440748 | http://purl.uniprot.org/core/title | "USP39 is essential for mammalian epithelial morphogenesis through upregulation of planar cell polarity components."xsd:string |
| http://purl.uniprot.org/citations/35440748 | http://purl.uniprot.org/core/title | "USP39 is essential for mammalian epithelial morphogenesis through upregulation of planar cell polarity components."xsd:string |
| http://purl.uniprot.org/citations/35440748 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/35440748 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/35440748 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35440748 |
| http://purl.uniprot.org/citations/35440748 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35440748 |