| http://purl.uniprot.org/citations/35444273 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35444273 | http://www.w3.org/2000/01/rdf-schema#comment | "All tissue-resident macrophages of the central nervous system (CNS)-including parenchymal microglia, as well as CNS-associated macrophages (CAMs1) such as meningeal and perivascular macrophages2-7-are part of the CNS endogenous innate immune system that acts as the first line of defence during infections or trauma2,8-10. It has been suggested that microglia and all subsets of CAMs are derived from prenatal cellular sources in the yolk sac that were defined as early erythromyeloid progenitors11-15. However, the precise ontogenetic relationships, the underlying transcriptional programs and the molecular signals that drive the development of distinct CAM subsets in situ are poorly understood. Here we show, using fate-mapping systems, single-cell profiling and cell-specific mutants, that only meningeal macrophages and microglia share a common prenatal progenitor. By contrast, perivascular macrophages originate from perinatal meningeal macrophages only after birth in an integrin-dependent manner. The establishment of perivascular macrophages critically requires the presence of arterial vascular smooth muscle cells. Together, our data reveal a precisely timed process in distinct anatomical niches for the establishment of macrophage subsets in the CNS."xsd:string |
| http://purl.uniprot.org/citations/35444273 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41586-022-04596-2"xsd:string |
| http://purl.uniprot.org/citations/35444273 | http://purl.uniprot.org/core/author | "Krueger M."xsd:string |
| http://purl.uniprot.org/citations/35444273 | http://purl.uniprot.org/core/author | "Masuda T."xsd:string |
| http://purl.uniprot.org/citations/35444273 | http://purl.uniprot.org/core/author | "Tsuda M."xsd:string |
| http://purl.uniprot.org/citations/35444273 | http://purl.uniprot.org/core/author | "Frosch M."xsd:string |
| http://purl.uniprot.org/citations/35444273 | http://purl.uniprot.org/core/author | "He L."xsd:string |
| http://purl.uniprot.org/citations/35444273 | http://purl.uniprot.org/core/author | "Betsholtz C."xsd:string |
| http://purl.uniprot.org/citations/35444273 | http://purl.uniprot.org/core/author | "Fliegauf M."xsd:string |
| http://purl.uniprot.org/citations/35444273 | http://purl.uniprot.org/core/author | "Yamasaki A."xsd:string |
| http://purl.uniprot.org/citations/35444273 | http://purl.uniprot.org/core/author | "Knobeloch K.P."xsd:string |
| http://purl.uniprot.org/citations/35444273 | http://purl.uniprot.org/core/author | "Lendahl U."xsd:string |
| http://purl.uniprot.org/citations/35444273 | http://purl.uniprot.org/core/author | "Joutel A."xsd:string |
| http://purl.uniprot.org/citations/35444273 | http://purl.uniprot.org/core/author | "Schreiner D."xsd:string |
| http://purl.uniprot.org/citations/35444273 | http://purl.uniprot.org/core/author | "Prinz M."xsd:string |
| http://purl.uniprot.org/citations/35444273 | http://purl.uniprot.org/core/author | "Daneman R."xsd:string |
| http://purl.uniprot.org/citations/35444273 | http://purl.uniprot.org/core/author | "Priller J."xsd:string |
| http://purl.uniprot.org/citations/35444273 | http://purl.uniprot.org/core/author | "Paterson N."xsd:string |
| http://purl.uniprot.org/citations/35444273 | http://purl.uniprot.org/core/author | "Grothe C."xsd:string |
| http://purl.uniprot.org/citations/35444273 | http://purl.uniprot.org/core/author | "Monaco G."xsd:string |
| http://purl.uniprot.org/citations/35444273 | http://purl.uniprot.org/core/author | "Lammermann T."xsd:string |
| http://purl.uniprot.org/citations/35444273 | http://purl.uniprot.org/core/author | "Staszewski O."xsd:string |
| http://purl.uniprot.org/citations/35444273 | http://purl.uniprot.org/core/author | "Hagemeyer N."xsd:string |
| http://purl.uniprot.org/citations/35444273 | http://purl.uniprot.org/core/author | "Kierdorf K."xsd:string |