| http://purl.uniprot.org/citations/35477937 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35477937 | http://www.w3.org/2000/01/rdf-schema#comment | "Class B1 of G protein-coupled receptors (GPCRs) comprises 15 members activated by physiologically important peptide hormones. Among them, vasoactive intestinal polypeptide receptor 2 (VIP2R) is expressed in the central and peripheral nervous systems and involved in a number of pathophysiological conditions, including pulmonary arterial hypertension, autoimmune and psychiatric disorders, in which it is thus a valuable drug target. Here, we report the cryo-electron microscopy structure of the human VIP2R bound to its endogenous ligand PACAP27 and the stimulatory G protein. Different from all reported peptide-bound class B1 GPCR structures, the N-terminal α-helix of VIP2R adopts a unique conformation that deeply inserts into a cleft between PACAP27 and the extracellular loop 1, thereby stabilizing the peptide-receptor interface. Its truncation or extension significantly decreased VIP2R-mediated cAMP accumulation. Our results provide additional information on peptide recognition and receptor activation among class B1 GPCRs and may facilitate the design of better therapeutics."xsd:string |
| http://purl.uniprot.org/citations/35477937 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-022-30041-z"xsd:string |
| http://purl.uniprot.org/citations/35477937 | http://purl.uniprot.org/core/author | "Chen C.W."xsd:string |
| http://purl.uniprot.org/citations/35477937 | http://purl.uniprot.org/core/author | "Jiang Y."xsd:string |
| http://purl.uniprot.org/citations/35477937 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/35477937 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/35477937 | http://purl.uniprot.org/core/author | "Xu Y."xsd:string |
| http://purl.uniprot.org/citations/35477937 | http://purl.uniprot.org/core/author | "Yang D."xsd:string |
| http://purl.uniprot.org/citations/35477937 | http://purl.uniprot.org/core/author | "Zhou Q."xsd:string |
| http://purl.uniprot.org/citations/35477937 | http://purl.uniprot.org/core/author | "Yan J."xsd:string |
| http://purl.uniprot.org/citations/35477937 | http://purl.uniprot.org/core/author | "Zhao F."xsd:string |
| http://purl.uniprot.org/citations/35477937 | http://purl.uniprot.org/core/author | "Xu H.E."xsd:string |
| http://purl.uniprot.org/citations/35477937 | http://purl.uniprot.org/core/author | "Feng W."xsd:string |
| http://purl.uniprot.org/citations/35477937 | http://purl.uniprot.org/core/author | "Xia T."xsd:string |
| http://purl.uniprot.org/citations/35477937 | http://purl.uniprot.org/core/author | "Liang A."xsd:string |
| http://purl.uniprot.org/citations/35477937 | http://purl.uniprot.org/core/author | "Zhao L.H."xsd:string |
| http://purl.uniprot.org/citations/35477937 | http://purl.uniprot.org/core/author | "Dai A."xsd:string |
| http://purl.uniprot.org/citations/35477937 | http://purl.uniprot.org/core/author | "Wang M.W."xsd:string |
| http://purl.uniprot.org/citations/35477937 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35477937 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/35477937 | http://purl.uniprot.org/core/pages | "2272"xsd:string |
| http://purl.uniprot.org/citations/35477937 | http://purl.uniprot.org/core/title | "A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2."xsd:string |
| http://purl.uniprot.org/citations/35477937 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/35477937 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35477937 |