| http://purl.uniprot.org/citations/35480562 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35480562 | http://www.w3.org/2000/01/rdf-schema#comment | "Allergic rhinitis (AR) is a common allergic disease characterized by disruption of nasal epithelial barrier. In this study, we investigated the mRNA expression of zonula occludens-1 (ZO-1), ZO-2 and ZO-3 and histone deacetylase 1 (HDAC1) and HDAC2 in AR patients compared to healthy controls. RNA samples were extracted from nasal epithelial cells of house dust mites (HDMs)-sensitized AR patients and healthy controls (n = 28 in each group). The RNAs were reverse transcribed into cDNAs for measurement of ZO-1, ZO-2, ZO-3, HDAC1 and HDAC2 expression levels by quantitative PCR. The mRNA expression of ZO-1 was significantly decreased in AR patients compared to healthy controls (p = 0.010). No significant difference was observed in the expression levels of ZO-2, ZO-3, HDAC1 and HDAC2 in AR patients compared to healthy controls. We found significant associations of higher HDAC2 levels in AR patients with lower frequency of changing bedsheet (p = 0.043) and with AR patients sensitized to Dermatophagoides farinae (p = 0.041). Higher expression of ZO-2 was observed in AR patients who had pets (p = 0.007). In conclusion, our data indicated that ZO-1 expression was lower in AR patients contributing to decreased integrity of nasal epithelial barrier integrity, and HDAC2 may be involved in the pathogenesis of the disease."xsd:string |
| http://purl.uniprot.org/citations/35480562 | http://purl.org/dc/terms/identifier | "doi:10.7717/peerj.13314"xsd:string |
| http://purl.uniprot.org/citations/35480562 | http://purl.uniprot.org/core/author | "Wong K.K."xsd:string |
| http://purl.uniprot.org/citations/35480562 | http://purl.uniprot.org/core/author | "Md Shukri N."xsd:string |
| http://purl.uniprot.org/citations/35480562 | http://purl.uniprot.org/core/author | "Mohd Ashari N.S."xsd:string |
| http://purl.uniprot.org/citations/35480562 | http://purl.uniprot.org/core/author | "Nur Husna S.M."xsd:string |
| http://purl.uniprot.org/citations/35480562 | http://purl.uniprot.org/core/author | "Siti Sarah C.O."xsd:string |
| http://purl.uniprot.org/citations/35480562 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35480562 | http://purl.uniprot.org/core/name | "PeerJ"xsd:string |
| http://purl.uniprot.org/citations/35480562 | http://purl.uniprot.org/core/pages | "e13314"xsd:string |
| http://purl.uniprot.org/citations/35480562 | http://purl.uniprot.org/core/title | "Zonula occludens-1 expression is reduced in nasal epithelial cells of allergic rhinitis patients."xsd:string |
| http://purl.uniprot.org/citations/35480562 | http://purl.uniprot.org/core/volume | "10"xsd:string |
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