| http://purl.uniprot.org/citations/35501825 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35501825 | http://www.w3.org/2000/01/rdf-schema#comment | "Previous studies have revealed that miRNAs participate in the pathogenesis of ovarian cancer; however, whether miR-600 is also involved remains unclear. In this study, we aimed to investigated the role of miR-600 in ovarian cancer progression. Here, miR-600 expression was significantly upregulated in ovarian cancer tissues and stem cells. Functional studies showed that miR-600 promoted ovarian cancer cell stemness, proliferation and metastasis. Mechanistic studies revealed that Kruppel like factor 9 (KLF9) was indicated as the target of miR-600. The luciferase reporter assay suggested that miR-600 directly bound to the 3'-untranslated region of KLF9. Additionally, miR-600 expression was negatively associated with KLF9 expression in human ovarian cancer tissues. Si-KLF9 partially abolished the discrepancy of self-renewal, growth and metastasis capacity between miR-600 knockdown ovarian cancer cells and control cells. In conclusion, our results suggest that miR-600 promotes ovarian cancer cell stemness, proliferation and metastasis via directly downregulating KLF9, and impairing miR-600 levels may be a new treatment strategy for ovarian cancer in the future."xsd:string |
| http://purl.uniprot.org/citations/35501825 | http://purl.org/dc/terms/identifier | "doi:10.1186/s13048-022-00981-7"xsd:string |
| http://purl.uniprot.org/citations/35501825 | http://purl.uniprot.org/core/author | "An N."xsd:string |
| http://purl.uniprot.org/citations/35501825 | http://purl.uniprot.org/core/author | "Ge J."xsd:string |
| http://purl.uniprot.org/citations/35501825 | http://purl.uniprot.org/core/author | "Qi Y."xsd:string |
| http://purl.uniprot.org/citations/35501825 | http://purl.uniprot.org/core/author | "Zhao H."xsd:string |
| http://purl.uniprot.org/citations/35501825 | http://purl.uniprot.org/core/author | "Xia Y."xsd:string |
| http://purl.uniprot.org/citations/35501825 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/35501825 | http://purl.uniprot.org/core/author | "Song P."xsd:string |
| http://purl.uniprot.org/citations/35501825 | http://purl.uniprot.org/core/author | "Shan L."xsd:string |
| http://purl.uniprot.org/citations/35501825 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35501825 | http://purl.uniprot.org/core/name | "J Ovarian Res"xsd:string |
| http://purl.uniprot.org/citations/35501825 | http://purl.uniprot.org/core/pages | "52"xsd:string |
| http://purl.uniprot.org/citations/35501825 | http://purl.uniprot.org/core/title | "miR-600 promotes ovarian cancer cells stemness, proliferation and metastasis via targeting KLF9."xsd:string |
| http://purl.uniprot.org/citations/35501825 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/35501825 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35501825 |
| http://purl.uniprot.org/citations/35501825 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35501825 |
| http://purl.uniprot.org/uniprot/#_B5BUG8-mappedCitation-35501825 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35501825 |
| http://purl.uniprot.org/uniprot/#_Q13886-mappedCitation-35501825 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35501825 |
| http://purl.uniprot.org/uniprot/Q13886 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/35501825 |
| http://purl.uniprot.org/uniprot/B5BUG8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/35501825 |