| http://purl.uniprot.org/citations/35526080 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35526080 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundInterleukin-2 (IL-2) and the high-affinity IL-2 receptor (IL-2R) are essential for the survival of regulatory T cells (Tregs) which are the main players in immune tolerance and prevention of autoimmune diseases. Sjögren's syndrome (SS) is a chronic autoimmune disease predominantly affecting women and is characterised by sicca symptoms including oral and ocular dryness. The aim of this study was to investigate an association between IL-2R and Treg function in patients with SS of different severity defined by the salivary flow rate.MethodsIn a cross-sectional study, we determined plasma soluble IL-2R (sIL-2R) levels in women with SS (n=97) and healthy females (n=50) using ELISA. A subset of those (n=51) was screened for Treg function measured by the STAT5 signalling response to IL-2 using phospho-flow cytometry.ResultsWe found that elevated plasma levels of sIL-2R were positively associated with the severity of SS reflected by a pathologically low salivary flow. Phospho-flow analysis revealed that patients with SS have a significantly lower frequency of pSTAT5+ Tregs upon IL-2 stimulation compared with healthy individuals, while the frequency of Tregs and pSTAT5 in conventional T cells remained unchanged. In addition, we observed more pSTAT5+ Tregs at baseline in patients with SS, which is significantly associated with seropositivity and elevated sIL-2R.ConclusionsOur data indicates that Tregs have a weakened immunosuppressive function in patients with SS due to impaired IL-2/IL-2R signalling capacity. This could mediate lymphocytic infiltration into salivary glands inducing sicca symptoms. We believe that sIL-2R could act as a useful indicator for SS and disease severity."xsd:string |
| http://purl.uniprot.org/citations/35526080 | http://purl.org/dc/terms/identifier | "doi:10.1186/s13075-022-02769-y"xsd:string |
| http://purl.uniprot.org/citations/35526080 | http://purl.uniprot.org/core/author | "Davies R."xsd:string |
| http://purl.uniprot.org/citations/35526080 | http://purl.uniprot.org/core/author | "Appel S."xsd:string |
| http://purl.uniprot.org/citations/35526080 | http://purl.uniprot.org/core/author | "Lyssenko V."xsd:string |
| http://purl.uniprot.org/citations/35526080 | http://purl.uniprot.org/core/author | "Jonsson R."xsd:string |
| http://purl.uniprot.org/citations/35526080 | http://purl.uniprot.org/core/author | "Bergum B."xsd:string |
| http://purl.uniprot.org/citations/35526080 | http://purl.uniprot.org/core/author | "Brun J.G."xsd:string |
| http://purl.uniprot.org/citations/35526080 | http://purl.uniprot.org/core/author | "Keindl M."xsd:string |
| http://purl.uniprot.org/citations/35526080 | http://purl.uniprot.org/core/author | "Hammenfors D."xsd:string |
| http://purl.uniprot.org/citations/35526080 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35526080 | http://purl.uniprot.org/core/name | "Arthritis Res Ther"xsd:string |
| http://purl.uniprot.org/citations/35526080 | http://purl.uniprot.org/core/pages | "101"xsd:string |
| http://purl.uniprot.org/citations/35526080 | http://purl.uniprot.org/core/title | "Impaired activation of STAT5 upon IL-2 stimulation in Tregs and elevated sIL-2R in Sjogren's syndrome."xsd:string |
| http://purl.uniprot.org/citations/35526080 | http://purl.uniprot.org/core/volume | "24"xsd:string |
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